Flubrotizolam

Flubrotizolam (2-bromo-4-(2-fluorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine) is a thienotriazolodiazepine derivative with potent sedative and anxiolytic effects, which has been sold as a designer drug.[1][2][3]

Flubrotizolam
Legal status
Legal status
Identifiers
IUPAC name
  • 4-bromo-7-(2-fluorophenyl)-13-methyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaene
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H10BrFN4S
Molar mass377.24 g·mol−1
3D model (JSmol)
SMILES
  • CC1=NN=C2N1C3=C(C=C(S3)Br)C(=NC2)C4=CC=CC=C4F
InChI
  • InChI=1S/C15H10BrFN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3
  • Key:VOZDBDBHBXLWCG-UHFFFAOYSA-N

See also

References
  1. US 4094984, Weber KH, Bauer A, Danneburg P, Kuhn FJ, "6-Phenyl-8-bromo-4H-s-triazolo-[3,4C]-thieno-[2,3E]-1,4-diazepines and salts thereof.", issued 13 June 1978, assigned to Boehringer Ingelheim
  2. Catalani V, Botha M, Corkery JM, Guirguis A, Vento A, Scherbaum N, Schifano F (July 2021). "The Psychonauts' Benzodiazepines; Quantitative Structure-Activity Relationship (QSAR) Analysis and Docking Prediction of Their Biological Activity". Pharmaceuticals. Basel, Switzerland. 14 (8): 720. doi:10.3390/ph14080720. PMC 8398354. PMID 34451817.
  3. Catalani, Valeria; Floresta, Giuseppe; Botha, Michelle; Corkery, John Martin; Guirguis, Amira; Vento, Alessandro; Abbate, Vincenzo; Schifano, Fabrizio (July 2022). "In silico studies on recreational drugs: 3D‐QSAR prediction of classified and de novo designer benzodiazepines". Chemical Biology & Drug Design. doi:10.1111/cbdd.14119. ISSN 1747-0277. PMID 35838189.



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