Iclazepam

Iclazepam (Clazepam) is a drug which is a benzodiazepine derivative. It has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, and is around the same potency as chlordiazepoxide.

Iclazepam
Identifiers
IUPAC name
  • 7-chloro-1-[2-(cyclopropylmethoxy)ethyl]-5-phenyl-3H-1,4-benzodiazepin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H21ClN2O2
Molar mass368.86 g·mol−1
3D model (JSmol)
SMILES
  • ClC1=CC2=C(C=C1)N(CCOCC3CC3)C(CN=C2C4=CC=CC=C4)=O
InChI
  • InChI=1S/C21H21ClN2O2/c22-17-8-9-19-18(12-17)21(16-4-2-1-3-5-16)23-13-20(25)24(19)10-11-26-14-15-6-7-15/h1-5,8-9,12,15H,6-7,10-11,13-14H2 Y
  • Key:PLRHQQPBNXIHAZ-UHFFFAOYSA-N Y
  (verify)

Iclazepam is a derivative of nordazepam substituted with a cyclopropylmethoxyethyl group on the N1 nitrogen. Once in the body, iclazepam is quickly metabolised to nordazepam and its N-(2-hydroxyethyl) derivative, which are thought to be mainly responsible for its effects.[1]

See also

References
  1. Giudicelli JF, Berdeaux A, Idrissi N, Richer C (January 1978). "Clazepam: pharmacokinetics and effects on performance". British Journal of Clinical Pharmacology. 5 (1): 65–9. doi:10.1111/j.1365-2125.1978.tb01599.x. PMC 1429233. PMID 23135.
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