Taniplon

Taniplon is a nonbenzodiazepine anxiolytic drug from the imidazoquinazoline family of drugs.

Taniplon
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • 3-(5-methoxy-6,7,8,9-tetrahydroimidazo[1,2-a]quinazolin-2-yl)-5-methyl-1,2,4-oxadiazole
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H15N5O2
Molar mass285.307 g·mol−1
3D model (JSmol)
SMILES
  • CC1=NC(C2=CN3C(N=C(OC)C4=C3CCCC4)=N2)=NO1
InChI
  • InChI=1S/C14H15N5O2/c1-8-15-12(18-21-8)10-7-19-11-6-4-3-5-9(11)13(20-2)17-14(19)16-10/h7H,3-6H2,1-2H3 N
  • Key:OYKONKGGKFFMDV-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

Taniplon binds strongly to benzodiazepine sites on the GABAA receptor and has similar anxiolytic effects in animals, but with less sedative or muscle relaxant action.[1]

References
  1. Tully WR, Gardner CR, Gillespie RJ, Westwood R (July 1991). "2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors". Journal of Medicinal Chemistry. 34 (7): 2060–7. doi:10.1021/jm00111a021. PMID 1648620.
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