CGS-9896

CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.[1]

CGS-9896
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • 2-(4-chlorophenyl)-1H-pyrazolo[4,5-c]quinolin-3-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H10ClN3O
Molar mass295.73 g·mol−1
3D model (JSmol)
SMILES
  • C1=CC=C2C(=C1)C3=C(C=N2)C(=O)N(N3)C4=CC=C(C=C4)Cl
InChI
  • InChI=1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,19H N
  • Key:QCBUAKLOWCOUCR-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

CGS-9896 is a benzodiazepine receptor partial agonist which produces long-lasting anxiolytic and anticonvulsant effects in animal studies but does not produce sedative effects.[2][3] It also increases appetite,[4] and reduces the development of gastrointestinal ulcers following chronic stress.[5]

References
  1. Leidenheimer NJ, Schechter MD (Oct 1988). "Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex". Pharmacol Biochem Behav. 31 (2): 249–54. doi:10.1016/0091-3057(88)90342-5. PMID 2854261. S2CID 21773709.
  2. Bernasconi R, Marescaux C, Vergnes M, et al. (1988). "Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models". J Neural Transm. 71 (1): 11–27. doi:10.1007/BF01259406. PMID 3343593. S2CID 31525533.
  3. Rump S, Raszewski W, Gidynska T, Galecka E (1990). "Effects of CGS 9896 in acute experimental intoxication with fluostigmine". Arch. Toxicol. 64 (5): 412–3. doi:10.1007/BF01973465. PMID 2206111. S2CID 19084019.
  4. Chen SW, Davies MF, Loew GH (1995). "Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake". Pharmacol Biochem Behav. 51 (2–3): 499–503. doi:10.1016/0091-3057(95)00020-W. PMID 7667375. S2CID 32809713.
  5. Najim RA, Karim KH (Feb 1990). "Effect of CGS 9896 on stress-induced gastric ulcer in rat". Clin Exp Pharmacol Physiol. 17 (2): 157–161. doi:10.1111/j.1440-1681.1990.tb01298.x. PMID 2109664. S2CID 37492286.


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