Fasiplon

Fasiplon (RU 33203) is a nonbenzodiazepine anxiolytic drug from the imidazopyrimidine family of drugs.

Fasiplon
Clinical data
ATC code
  • none
Identifiers
IUPAC name
  • 6-Ethyl-7-methoxy-5-methyl-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-imidazo[1,2-a]pyrimidine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H15N5O2
Molar mass273.296 g·mol−1
3D model (JSmol)
SMILES
  • CC1=NC(C2=CN3C(N=C(OC)C(CC)=C3C)=N2)=NO1
InChI
  • InChI=1S/C13H15N5O2/c1-5-9-7(2)18-6-10(11-14-8(3)20-17-11)15-13(18)16-12(9)19-4/h6H,5H2,1-4H3 N
  • Key:MEBYKPLMXIRYRQ-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

Fasiplon binds strongly to benzodiazepine sites on the GABAA receptor and has similar anxiolytic effects in animals, but with less sedative or muscle relaxant action.[1] It was developed by a team at Roussel Uclaf in the 1990s[2]

References
  1. Tully WR, Gardner CR, Gillespie RJ, Westwood R (July 1991). "2-(oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors". Journal of Medicinal Chemistry. 34 (7): 2060–7. doi:10.1021/jm00111a021. PMID 1648620.
  2. US Patent 5869481 Anticonvulsive 1-ar(alk)ylimidazolin-2-ones and process for making
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