Deschloroetizolam

Deschloroetizolam (also known as Etizolam-2) is a thienotriazolodiazepine that is the dechlorinated analog of the closely related etizolam.[1][2][3] The compound has been sold as a designer drug.[4][5][6][7]

Deschloroetizolam
Clinical data
Dependence
liability		Moderate
Routes of
administration		Oral, sublingual, rectal
Legal status
Legal status
Identifiers
IUPAC name
  • 4-phenyl-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC17H16N4S
Molar mass308.40 g·mol−1
3D model (JSmol)
SMILES
  • CCC1=CC2=C(S1)N3C(=NN=C3CN=C2C4=CC=CC=C4)C
InChI
  • InChI=1S/C17H16N4S/c1-3-13-9-14-16(12-7-5-4-6-8-12)18-10-15-20-19-11(2)21(15)17(14)22-13/h4-9H,3,10H2,1-2H3
  • Key:JIOBORXCOGMHSV-UHFFFAOYSA-N

Deschloroetizolam is classified and controlled as a hazardous substance in Sweden as of on October 15, 2015.[8]

See also

References
  1. Weber KH, Bauer A, Langbein A, Daniel H (September 1978). "Heteroaromaten mit anellierten Siebenringen, III. Umwandlung von Thienotriazolooxazepinen in Diazepine". Justus Liebigs Annalen der Chemie (in German). 1978 (8): 1257–1265. doi:10.1002/jlac.197819780806.
  2. US 3904641, Nakanishi M, Tahara T, Araki K, Shiroki M, "Triazolothienodiazepine compounds", published 1975-09-09, assigned to Yoshitomi Pharmaceutical Industries, Ltd.
  3. EP 0776892, Hiroshi K, Syuji E, Hideaki S, Minoru M, Kenichi O, "Thienylazole compound and thienotriazolodiazepine compound", published 4 June 1997, assigned to Yoshitomi Pharmaceutical Industries, Ltd.
  4. "Deschloroetizolam". New Synthetic Drugs Database.
  5. Pettersson Bergstrand M, Helander A, Hansson T, Beck O (April 2017). "Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays". Drug Testing and Analysis. 9 (4): 640–645. doi:10.1002/dta.2003. PMID 27366870.
  6. Manchester KR, Maskell PD, Waters L (March 2018). "a and plasma protein binding values for benzodiazepines appearing as new psychoactive substances" (PDF). Drug Testing and Analysis. 10 (8): 1258–1269. doi:10.1002/dta.2387. PMID 29582576.
  7. Manchester, Kieran R.; Waters, Laura; Haider, Shozeb; Maskell, Peter D. (2022). "The blood-to-plasma ratio and predicted GABAA-binding affinity of designer benzodiazepines". Forensic Toxicology. doi:10.1007/s11419-022-00616-y. ISSN 1860-8973.
  8. "Nya substanser klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 18 August 2015.
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