Firocoxib

Firocoxib
Firocoxib molecule
Clinical data
Trade namesEquioxx; Previcox
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATCvet code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
  • EU: Rx-only
  • Veterinary use only
Identifiers
IUPAC name
  • 3-(Cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H20O5S
Molar mass336.40 g·mol−1
3D model (JSmol)
SMILES
  • O=C2OC(C(=C2\OCC1CC1)\c3ccc(cc3)S(=O)(=O)C)(C)C
InChI
  • InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3 checkY
  • Key:FULAPETWGIGNMT-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Firocoxib (INN; brand names Equioxx and Previcox) is a nonsteroidal anti-inflammatory drug of the COX-2 inhibitor (coxib) class, currently approved for use in dogs and horses.[1] Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses.[2] Firocoxib is not intended or approved for use in human medicine.[3]

References

  1. ↑ Rangel-Nava A, Ramírez-Uribe JM, Recillas-Morales S, Ibancovichi-Camarillo JA, Venebra-Muñoz A, Sánchez-Aparicio P (June 2019). "Pharmacological Regulation in the USA and Pharmacokinetics Parameters of Firocoxib, a Highly Selective Cox-2, by Pain Management in Horses". Journal of Equine Veterinary Science. 77: 36–42. doi:10.1016/j.jevs.2019.02.007. PMID 31133314.
  2. ↑ "New NSAID Equioxx (firocoxib) Approved by USEF". The Horse. July 2, 2007. Retrieved 2008-04-18.
  3. ↑ Equioxx, European Medicines Agency


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