Ibuprofen/paracetamol

Ibuprofen/paracetamol
Combination of
IbuprofenNonsteroidal anti-inflammatory drug
ParacetamolAnalgesic/antipyretic
Clinical data
Trade namesCombiflam, Advil Dual Action, Ibupane
License data
Pregnancy
category
Routes of
administration
By mouth
ATC code
  • None
Legal status
Legal status
  • AU: S3 (Pharmacist only) / S2[1]
  • US: OTC
Identifiers
CAS Number
KEGG

Ibuprofen/paracetamol, sold under the brand name Combiflam among others, is a fixed-dose combination of the two medications, ibuprofen, and paracetamol (acetaminophen).[2] It is available in India,[2] the United States,[3][4] and Australia.[1] It may be used for fever, headache, muscle pain and menstrual cramps. Ibuprofen belongs to nonsteroidal anti-inflammatory drug (NSAID) class of drugs.

There is evidence that paracetamol combined with an NSAID provides pain relief better than either drug used alone.[5][6]

Adverse effects

References

  1. 1 2 3 "Ibupane" (PDF). TGA eBS.
  2. 1 2 "Combiflam". drugs.com. Retrieved 5 February 2015.
  3. "Advil Dual Action: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 28 February 2020.
  4. "FDA approves GSK's Advil Dual Action with Acetaminophen for over-the-counter use in the United States" (Press release). GSK Consumer Healthcare. 28 February 2020. Retrieved 28 February 2020 via PR Newswire.
  5. Ong CK, Seymour RA, Lirk P, Merry AF (April 2010). "Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain". Anesthesia and Analgesia. 110 (4): 1170–9. doi:10.1213/ANE.0b013e3181cf9281. PMID 20142348. S2CID 7948680.
  6. Moore RA, Derry C (January 2013). "Efficacy of OTC analgesics". International Journal of Clinical Practice. Supplement. 67 (178): 21–5. doi:10.1111/ijcp.12054. PMID 23163544. S2CID 205184492.
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