Etazocine

Etazocine (NIH-7856) is an opioid analgesic of the benzomorphan family which was never marketed.[1][2] It acts as a partial agonist of the opioid receptors, with mixed agonist and antagonist effects.[1] In animal studies, it was shown to induce analgesia, dependency, and respiratory depression, with overall effects similar to those of morphine, but with substantially reduced potency in comparison.[1][2][3]

Etazocine
Clinical data
Other namesNIH-7856 ((±)-form);
GPA-208 ((−)-form);
GPA-2087 ((−)-form);
NIH-8178 ((−)-form);
FDA-0487 ((−)-form)
ATC code
  • None
Legal status
Legal status
  • In general: non-regulated
Identifiers
IUPAC name
  • 1,2,3,4,5,6-hexahydro-6,11-diethyl-3-methyl-2,6-methano-3-benzazocin-8-ol
    or
    5,7-diethyl-2-hydroxy-2-methyl-6,7-benzomorphan
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC17H25NO
Molar mass259.393 g·mol−1
3D model (JSmol)
SMILES
  • Oc1ccc3c(c1)[C@@]2([C@H]([C@@H](N(CC2)C)C3)CC)CC
InChI
  • InChI=1S/C17H25NO/c1-4-14-16-10-12-6-7-13(19)11-15(12)17(14,5-2)8-9-18(16)3/h6-7,11,14,16,19H,4-5,8-10H2,1-3H3/t14-,16-,17-/m0/s1
  • Key:JYRBQCWXZNDERM-XIRDDKMYSA-N

See also
  • Benzomorphan

References
  1. National Research Council (U.S.). Committee on Problems of Drug Dependence, American Medical Association. Committee on Alcoholism and Drug Dependence, American Medical Association. Council on Mental Health, National Academy of Sciences (U.S.) (1969). Bulletin, problems of drug dependence. National Academies. pp. 5820–5821. NAP:10503. Retrieved 22 April 2012.
  2. Smethurst PW, Forrest WH, Hayden J (December 1971). "The respiratory effects of a potent analgesic (GPA 2087) in man". British Journal of Anaesthesia. 43 (12): 1129–35. doi:10.1093/bja/43.12.1129. PMID 5156297.
  3. National Research Council (U.S.). Committee on Problems of Drug Dependence (1970). Report of the annual scientific meeting. National Research Council. Retrieved 22 April 2012.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.