PTI-609
PTI-609 is an opioid that binds to the protein scaffolding region of pentapeptide filamin A, which regulates mu-receptor signaling so that their activation should not result in opioid tolerance.
This mechanism also has been shown release inflammatory cytokines. PTI-609 binds with picomolar affinity and activates opioid recepts via a novel binding domain.[1]
See also
References
- H. Burns, Lindsay; Wang, Hoau-Yan (2010). "PTI-609: A Novel Analgesic that Binds Filamin A to Control Opioid Signaling". Recent Patents on CNS Drug Discovery. 5 (3): 210–220. doi:10.2174/157488910793362386. ISSN 1574-8898. PMID 20726836.
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