Trestolone enanthate

Trestolone enanthate, also known as 7α-methyl-19-nortestosterone 17β-enanthate (MENT enanthate), is an androgen and anabolic steroid (AAS) and progestogen which was never marketed.[1][2] It is an androgen ester; specifically, it is the C17β enanthate (heptanoate) ester of trestolone (7α-methylestr-4-en-17β-ol-3-one).[2] Trestolone enanthate has low affinity for sex hormone-binding globulin (SHBG), similarly to testosterone enanthate.[1]

Trestolone enanthate
Clinical data
Other namesTrestolone 17β-enanthate; MENT enanthate; 7α-Methyl-19-nortestosterone 17β-enanthate; 7α-Methylestr-4-en-17β-ol-3-one 17β-enanthate
Pregnancy
category
  • AU: D / X -->
Drug classAndrogen; Anabolic steroid; Androgen ester
Identifiers
IUPAC name
  • (7R,8R,9S,10R,13S,14S,17S)-7,13-Dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl heptanoate
CAS Number
UNII
Chemical and physical data
FormulaC26H40O3
Molar mass400.603 g·mol−1
3D model (JSmol)
SMILES
  • CCCCCCC(O[C@]1(CC[C@]2([C@@]3([C@@H](CC4=CC(CC[C@@]4([C@]3(CC[C@@]21C)[H])[H])=O)C)[H])[H])[H])=O
InChI
  • InChI=1S/C26H40O3/c2+4+8+16+32+64+128(336)1+1(2)2+25(27)2+8+8(18)21(25)13-14-26(22,23)3/h16-17,20-23,25H,4-15H2,1-3H3/t17-,20+,21-,22+,23+,25-,26+/m1/s1
  • Key:YHLLSSBURKVUEG-YFGHHJRWSA-N

See also

References
  1. Cunningham GR, Tindall DJ, Lobl TJ, Campbell JA, Means AR (September 1981). "Steroid structural requirements for high affinity binding to human sex steroid binding protein (SBP)". Steroids. 38 (3): 243–62. doi:10.1016/0039-128X(81)90061-1. PMID 7197818. S2CID 2702353.
  2. Bursi R, Grootenhuis A, van der Louw J, Verhagen J, de Gooyer M, Jacobs P, Leysen D (March 2003). "Structure-activity relationship study of human liver microsomes-catalyzed hydrolysis rate of ester prodrugs of MENT by comparative molecular field analysis (CoMFA)". Steroids. 68 (3): 213–220. doi:10.1016/S0039-128X(02)00186-1. PMID 12628684. S2CID 32309966.



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