Amlodipine/benazepril

Amlodipine/benazepril
Combination of
AmlodipineCalcium channel blocker
BenazeprilACE inhibitor
Names
Trade namesLotrel
Clinical data
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • US: D (Evidence of risk)
    Routes of
    use
    By mouth
    External links
    AHFS/Drugs.comProfessional Drug Facts
    Legal
    License data
    Legal status

    Amlodipine/benazepril, marketed as Lotrel among others, is a medication used to treat high blood pressure.[1] It is a combination of amlodipine, a calcium channel blocker and benazepril, an angiotensin converting enzyme inhibitor.[1] It may be used if a single agent is not sufficient.[1] It is taken by mouth.[1]

    Common side effects include cough, dizziness, and swelling.[1] Serious side effects may include angioedema, myocardial infarction, high blood potassium, liver problems, and low blood pressure.[1] Use in pregnancy is not recommended.[1] Amlodipine works by increasing the size of arteries while benazepril works by decreasing renin-angiotensin-aldosterone system activity.[1]

    The combination was approved for medical use in the United States in 1995.[2] It is available as a generic medication.[3] A month supply in the United States has a wholesale cost of about US$4.50.[4] In 2017, it was the 160th most commonly prescribed medication in the United States, with more than three million prescriptions.[5][6]

    Medical use

    It is used to treat high blood pressure.[1] It is not a first line treatment.[7]

    Cost

    A month supply in the United States has a wholesale cost of about US$4.50.[4] In 2017, it was the 160th most commonly prescribed medication in the United States, with more than three million prescriptions.[5][6]

    References

    1. 1 2 3 4 5 6 7 8 9 "Amlodipine besylate and benazepril hydrochloride- amlodipine besylate and benazepril hydrochloride capsule". DailyMed. U.S. National Library of Medicine. Archived from the original on 17 May 2020. Retrieved 10 March 2019.
    2. Cerner Multum. "Amlodipine and benazepril Uses, Side Effects & Warnings". Drugs.com. Archived from the original on 20 August 2016. Retrieved 10 March 2019.
    3. Bope, Edward T.; Kellerman, Rick D. (2016). Conn's Current Therapy 2017 E-Book. Elsevier Health Sciences. p. 124. ISBN 978-0-323-44335-7. Archived from the original on 2020-08-07. Retrieved 2020-07-11.
    4. 1 2 "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
    5. 1 2 "The Top 300 of 2020". ClinCalc DrugStats Database. ClinCalc LLC. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
    6. 1 2 "Amlodipine Besylate; Benazepril Hydrochloride - Drug Usage Statistics". ClinCalc DrugStats Database. ClinCalc LLC. Archived from the original on 11 April 2020. Retrieved 11 April 2020.
    7. Faulkner MA, Hilleman DE (January 2001). "Amlodipine/benazepril: fixed dose combination therapy for hypertension". Expert Opinion on Pharmacotherapy. 2 (1): 165–78. doi:10.1517/14656566.2.1.165. PMID 11336577. S2CID 23021242.
    Identifiers:
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