Epinastine

Epinastine
Names
Trade namesAlesion, Elestat, Purivist, Relestat
Other namesEpinastine hydrochloride
IUPAC name
  • (RS)-3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine
Clinical data
Drug classAntihistamine[1]
Main usesAllergic conjunctivitis[1]
Side effectsEye irritation[2]
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Pregnancy
category
  • C
Routes of
use		Eye drops
Onset of actionWithin 5 min[1]
Duration of action8 hrs[1]
External links
AHFS/Drugs.comMonograph
MedlinePlusa604011
Pharmacokinetics
Protein binding64%
Elimination half-life12 hours
Chemical and physical data
FormulaC16H15N3
Molar mass249.317 g·mol−1
3D model (JSmol)
SMILES
  • N\4=C(\N3c1c(cccc1)Cc2c(cccc2)C3C/4)N
InChI
  • InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18) checkY
  • Key:WHWZLSFABNNENI-UHFFFAOYSA-N checkY

Epinastine, sold under the brand name Elestat among others, is a medication used to treat allergic conjunctivitis.[1] It is used as an eye drop.[1] Effects begin within 5 minutes and last for up to 8 hours.[1] It may be used for up to 8 weeks.[2]

Common side effects include eye irritation.[2] Other side effects may include dry eye and change in taste.[2] It is an antihistamine and mast cell stabilizer.[1] It does not cross the blood-brain-barrier.[1]

Epinastine was patented in 1980 and came into medical use in 1994.[3] In the United Kingdom 5 ml cost the NHS about £10 as of 2021.[2] This amount in the United States costs about 31 USD.[4]

Medical uses

Dosage

It is used as one drop twice per day.[2][1]

References

  1. 1 2 3 4 5 6 7 8 9 10 "Epinastine Monograph for Professionals". Drugs.com. Archived from the original on 1 March 2021. Retrieved 15 December 2021.
  2. 1 2 3 4 5 6 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1205. ISBN 978-0857114105.
  3. ↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 549. ISBN 9783527607495. Archived from the original on 2020-12-27. Retrieved 2021-03-08.
  4. ↑ "Epinastine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 8 May 2016. Retrieved 15 December 2021.
Identifiers:
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