Dexbrompheniramine

Dexbrompheniramine
Names
Trade namesDrixoril, Conex, Dixaphedrine
Other namesDexbrompheniramine maleate
IUPAC name
  • (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
Clinical data
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    use    		Oral
    External links
    AHFS/Drugs.comMultum Consumer Information
    Legal
    Legal status
    Pharmacokinetics
    Elimination half-life25 hours
    Identifiers
    CAS Number
    • 132-21-8 checkY
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    UNII
    ChEBI
    ChEMBL
    ATC code
    Chemical and physical data
    FormulaC16H19BrN2
    Molar mass319.246 g·mol−1
    3D model (JSmol)
    SMILES
    • Brc1ccc(cc1)[C@@H](c2ncccc2)CCN(C)C
    InChI
    • InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1 checkY
    • Key:ZDIGNSYAACHWNL-HNNXBMFYSA-N checkY

    Dexbrompheniramine is an antihistamine with anticholinergic properties[1] used to treat allergic conditions such as hay fever or urticaria. It is the pharmacologically active dextrorotatory isomer of brompheniramine. It was formerly marketed in combination with pseudoephedrine under the name Drixoral in the US and Canada. It is an alkylamine antihistamine.

    Dexbrompheniramine is a first generation antihistamine that reduces the effects of the neurotransmitter histamine in the body; sneezing, itching, watery eyes, and runny nose.

    Society and culture

    Cost

    This medication in the U.S. is $19.93 (USD) for 30 tablets of 2 mg[2]

    • DexbrompheniramineMaleate costs (US)
      DexbrompheniramineMaleate costs (US)
    • DexbrompheniramineMaleate prescriptions (US)
      DexbrompheniramineMaleate prescriptions (US)

    Interactions

    • MAO inhibitors within 14 days. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
    • Potassium
    • Drinking alcohol can increase side effects of dexbrompheniramine.

    References

    1. ↑ Löfkvist T (1978). "A comparative evaluation of oral decongestants in the treatment of vasomotor rhinitis". The Journal of International Medical Research. 6 (1): 56–60. doi:10.1177/030006057800600110. PMID 627306. S2CID 39205584.
    2. ↑ "Dexbrompheniramine Maleate prices and discount coupons | America's Pharmacy". www.americaspharmacy.com. Archived from the original on 28 August 2021. Retrieved 27 March 2021.


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