Pimethixene

Pimethixene
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, nasal
ATC code
Identifiers
IUPAC name
  • 1-Methyl-4-(9H-thioxanthen-9-ylidene)piperidine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.005.675
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Chemical and physical data
FormulaC19H19NS
Molar mass293.43 g·mol−1
3D model (JSmol)
SMILES
  • S2c1ccccc1/C(c3c2cccc3)=C4/CCN(C)CC4
InChI
  • InChI=1S/C19H19NS/c1-20-12-10-14(11-13-20)19-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)19/h2-9H,10-13H2,1H3 checkY
  • Key:NZLVRVYNQYGMAB-UHFFFAOYSA-N checkY
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Pimethixene is an antihistamine and anticholinergic of the thioxanthene chemical class originally developed to treat hyperactivity,[1] anxiety, sleep disorders, and allergy. It is also used for anesthesia and as a bronchodilator (to dilate the bronchi and bronchioles for more airflow).

In combination with pholcodine, it was sold in France by Laboratoires Salvoxyl in the 1970s as the antitussive Salvodex.[2] Pimethixene alone is still available in Brazil under the trade name Muricalm.

See also

  • Thioxanthene

References

  1. ↑ Chefneux A (July 1978). "[New treatment of hyperkinesis in the child: pimethixene]". Revue Médicale de Liège. 33 (14): 500–3. PMID 674966.
  2. ↑ Bailly, Christian (8 December 2020). "Salvodex® (9-(1-methyl, 4-piperylidenyl)thiaxanthene and pholcodine), from Laboratoires Salvoxyl (Orléans), 1971". Oncowitan. Retrieved 4 January 2022.


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