Ulobetasol

Ulobetasol
Clinical data
Trade namesUltravate
Other names(6S,8S,9S,10S,11S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one, halobetasol (USAN US)
AHFS/Drugs.comProfessional Drug Facts
MedlinePlusa601060
ATC code
Identifiers
IUPAC name
  • (6α,11β,16β)-21-Chloro-6,9-difluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H27ClF2O4
Molar mass428.90 g·mol−1
3D model (JSmol)
SMILES
  • ClCC(=O)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@@H]3C)C)C
InChI
  • InChI=1S/C22H27ClF2O4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1 checkY
  • Key:LEHFPXVYPMWYQD-XHIJKXOTSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Ulobetasol (INN) or halobetasol (USAN) is a corticosteroid used to treat psoriasis.[1][2] It is a class I corticosteroid under the US classification and a group III corticosteroid under international classification, the most potent group of such drugs.[3][4]

Ulobetasol propionate is usually supplied as a 0.05% topical cream.[1] Ulobetasol is the strongest topical steroid available. It is also sold with tazarotene with 0.01% halobetasol and 0.045% tazarotene as a lotion branded as Duobrii (Bausch Health).

It is available as a generic medication.[5]

References

  1. 1 2 "Ultravate product monograph" (PDF). Retrieved 2021-01-04.
  2. ↑ DrugBank DB00596 . Retrieved 2020-01-04.
  3. ↑ Pearce DJ, Spencer L, Hu J, Balkrishnan R, Fleischer AB, Feldman SR (July 2004). "Class I topical corticosteroid use by psoriasis patients in an academic practice". The Journal of Dermatological Treatment. 15 (4): 235–8. doi:10.1080/09546630410033745. PMID 15764038. S2CID 2757493.
  4. ↑ ATC code D07AC21 (WHO). Retrieved 2020-01-04.
  5. ↑ "Ulobetasol international". Drugs.com. 10 August 2020. Retrieved 15 August 2020.
  • "Halobetasol". Drug Information Portal. U.S. National Library of Medicine.
  • "Halobetasol propionate". Drug Information Portal. U.S. National Library of Medicine.
  • halobetasol at the US National Library of Medicine Medical Subject Headings (MeSH)
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