Fluocortolone

Fluocortolone
Clinical data
Other names(6S,8S,9R,10S,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • (1S,2R,8S,10S,11S,13R,14S,15S,17S)-8-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.005.284
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Chemical and physical data
FormulaC22H29FO4
Molar mass376.468 g·mol−1
3D model (JSmol)
SMILES
  • O=C\1\C=C/[C@]4(/C(=C/1)[C@@H](F)C[C@@H]2[C@@H]4[C@@H](O)C[C@@]3([C@@H](C(=O)CO)[C@@H](C[C@@H]23)C)C)C
InChI
  • InChI=1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1 checkY
  • Key:GAKMQHDJQHZUTJ-ULHLPKEOSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Fluocortolone is a glucocorticoid[1] used in the treatment of several conditions, including hemorrhoids.

It is similar to fluocortin, but with one less keto group.

See also

References

  1. ↑ Munro DD, Wilson HT, Rhodes EL (November 1967). "Comparison of betamethasone 17-valerate ointment with fluocortolone and fluocortolone caproate ointment". British Medical Journal. 4 (5574): 275–6. doi:10.1136/bmj.4.5574.275. PMC 1748932. PMID 6054003.


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