Quinelorane

Quinelorane
Identifiers
	IUPAC name (5aR,9aR)-6-propyl-5a,7,8,9,9a,10-hexahydro-5H-pyrido[2,3-g]quinazolin-2-amine;
CAS Number	97466-90-5 ; HCl: 97548-97-5 ;
PubChem CID	57242;
IUPHAR/BPS	954;
ChemSpider	51604 ;
UNII	Z0X4VT3Y1Q; HCl: JT5527J55O ;
KEGG	D05677 ;
ChEMBL	ChEMBL155731 ;
CompTox Dashboard (EPA)	DTXSID4046315 ;
Chemical and physical data
Formula	C14H22N4
Molar mass	246.358 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCN1CCC[C@H]2[C@H]1CC3=CN=C(N=C3C2)N;
	InChI InChI=1S/C14H22N4/c1-2-5-18-6-3-4-10-7-12-11(8-13(10)18)9-16-14(15)17-12/h9-10,13H,2-8H2,1H3,(H2,15,16,17)/t10-,13-/m1/s1 ; Key:TUFADSGTJUOBEH-ZWNOBZJWSA-N ;
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Quinelorane is a drug which acts as a dopamine agonist for the D₂^[1]^[2]^[3] and D₃ receptor.

References

↑ Caine SB, Negus SS, Mello NK, Patel S, Bristow L, Kulagowski J, Vallone D, Saiardi A, Borrelli E (April 2002). "Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists". Journal of Neuroscience. 22 (7): 2977–88. doi:10.1523/JNEUROSCI.22-07-02977.2002. PMC 6758322. PMID 11923462.
↑ Gasior M, Paronis CA, Bergman J (January 2004). "Modification by dopaminergic drugs of choice behavior under concurrent schedules of intravenous saline and food delivery in monkeys". The Journal of Pharmacology and Experimental Therapeutics. 308 (1): 249–59. doi:10.1124/jpet.103.052795. PMID 14563783.
↑ Brooks JM, Sarter M, Bruno JP (September 2007). "D2-like receptors in nucleus accumbens negatively modulate acetylcholine release in prefrontal cortex". Neuropharmacology. 53 (3): 455–63. doi:10.1016/j.neuropharm.2007.06.006. PMC 2000917. PMID 17681559.

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