U-48800

U-48800
Identifiers
IUPAC name
  • 2-(2,4-dichlorophenyl)-N-[(1S,2S)-2-(dimethylamino)cyclohexyl]-N-methylacetamide
CAS Number
PubChem CID
Chemical and physical data
FormulaC17H24Cl2N2O
Molar mass343.29 g·mol−1
3D model (JSmol)
SMILES
  • CN(C)[C@H]1CCCC[C@@H]1N(C)C(=O)CC2=C(C=C(C=C2)Cl)Cl
InChI
  • InChI=1S/C17H24Cl2N2O/c1-20(2)15-6-4-5-7-16(15)21(3)17(22)10-12-8-9-13(18)11-14(12)19/h8-9,11,15-16H,4-7,10H2,1-3H3/t15-,16-/m0/s1
  • Key:FKUWIGXXBMULOI-HOTGVXAUSA-N

U-48800 is an opioid analgesic which has been sold as a designer drug. Unlike U-47700, it is primarily active as a kappa opioid receptor agonist with only moderate affinity at the mu opioid receptor. Nevertheless, it has still appeared on the recreational drug market, often as a component of combinations with other drugs, and has been linked to numerous drug overdose cases.[1][2][3][4][5]


See also

References

  1. ↑ Gampfer TM, Richter LHJ, Schäper J, Wagmann L, Meyer MR. Toxicokinetics and analytical toxicology of the abused opioid U-48800 - in vitro metabolism, metabolic stability, isozyme mapping, and plasma protein binding. Drug Test Anal. 2019 Oct;11(10):1572-1580. doi:10.1002/dta.2683 PMID 31424163
  2. ↑ Baumann MH, Tocco G, Papsun DM, Mohr AL, Fogarty MF, Krotulski AJ (November 2020). "U-47700 and Its Analogs: Non-Fentanyl Synthetic Opioids Impacting the Recreational Drug Market". Brain Sciences. 10 (11): 895. doi:10.3390/brainsci10110895. PMC 7700279. PMID 33238449.
  3. ↑ Fogarty MF, Mohr ALA, Papsun DM, Logan BK. Analysis of the Illicit Opioid U-48800 and Related Compounds by LC-MS-MS and Case Series of Fatalities Involving U-48800. J Anal Toxicol. 2022 Feb 14;46(1):17-24. doi:10.1093/jat/bkaa180 PMID 33237987
  4. ↑ Otte L, Wilde M, Auwärter V, Grafinger KE. Investigation of the μ- and κ-opioid receptor activation by eight new synthetic opioids using the [35 S]-GTPγS assay: U-47700, isopropyl U-47700, U-49900, U-47931E, N-methyl U-47931E, U-51754, U-48520, and U-48800. Drug Test Anal. 2022 Jul;14(7):1187-1199. doi:10.1002/dta.3238 PMID 35142070
  5. ↑ Amend N, Thiermann H, Worek F, Wille T. A pharmacologically pre-contracted smooth muscle bowel model for the study of highly-potent opioid receptor agonists and antagonists. Toxicol Lett. 2023 Jun 1;382:41-46. doi:10.1016/j.toxlet.2023.05.010 PMID 37245850


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