List of opioids

Opium poppy (Papaver somniferum) flower

This is a list of opioids, opioid antagonists and inverse agonists.

Opium and poppy straw derivatives

Seedhead of opium poppy with white latex

Crude opiate extracts whole opium products

Natural opiates

Opium alkaloids

Structures
Morphides
Codeine Morphine Oripavine Pseudomorphine Thebaine

Alkaloid salts mixtures

Semisynthetics including Bentley compounds

Morphine family

Structures of Morphine family
Morphine family
14-Hydroxymorphine 2,4-Dinitrophenylmorphine 6-Methyldihydromorphine 6-Methylenedihydrodesoxymorphine 6-Acetyldihydromorphine hydrochloride
Azidomorphine Chlornaltrexamine Chloroxymorphamine Desomorphine
(Dihydrodesoxymorphine)		 Dihydromorphine
Ethyldihydromorphine Hydromorphinol Methyldesorphine N-Phenethylnormorphine 6-nicotinoyldihydromorphine
RAM-378

3,6-diesters of morphine

Structures
3,6-diesters of morphine
Acetylpropionylmorphine 3,6-Dibutanoylmorphine Diacetyldihydromorphine
(dihydroheroin, acetylmorphinol)
Dibutyrylmorphine Dibenzoylmorphine Diformylmorphine
Dipropanoylmorphine Heroin
(diacetylmorphine)		 Nicomorphine

Codeine-dionine family

Structures
Codeine-dionine family
6-Monoacetylcodeine Benzylmorphine Codeine methylbromide Desocodeine Dimethylmorphine
(6-O-Methylcodeine)
Ethyldihydromorphine Methyldihydromorphine
(dihydroheterocodeine)		 Ethylmorphine Heterocodeine Isocodeine
Pholcodine Myrophine Transisocodeine

Morphinones and morphols

Structures
Morphinones and morphols
14-Cinnamoyloxycodeinone 14-Ethoxymetopon 14-Methoxymetopon 14-Phenylpropoxymetopon 7-Spiroindanyloxymorphone
8,14-Dihydroxydihydromorphinone Acetylcodone Acetylmorphone α-hydrocodol
(Dihydrocodeine)		 Bromoisopropropyldihydromorphinone
Codeinone Codorphone Codol
(Codeine Phosphate)		 Codoxime IBNtxA
Thebacon Hydrocodone Hydromorphone Hydroxycodeine Metopon
(methyldihydromorphinone)
Morphenol Morphinone Morphol N-Phenethyl-14-ethoxymetopon Oxycodone
Oxymorphol Oxymorphone Pentamorphone Semorphone

Morphides

  • α-Chlorocodide (= chlorocodide) 
  • β-Chlorocodide 
  • α-Chloromorphide (= chloromorphide)
  • Bromocodide 
  • Bromomorphide 
  • Chlorodihydrocodide 
  • Chloromorphide
  • Codide 
Structures
Morphides
α-chlorocodide β-chlorocodide Bromomorphide
Chlorodihydrocodide. Chloromorphide Codide

Dihydrocodeine series

Structures
Morphides
14-Hydroxydihydrocodeine Acetyldihydrocodeine Dihydrocodeine Dihydrodesoxycodeine
Dihydroisocodeine Nicocodeine Nicodicodeine

Nitrogen morphine derivatives

Structures
Morphides
1-Nitrocodeine Codeine-N-oxide Morphine-N-oxide

Hydrazones

Structures
Hydrazones
Oxymorphazone

Halogenated morphine derivatives

  • 1-Bromocodeine 
  • 1-Chlorocodeine 
  • 1-Iodomorphine
Structures
Other open chain opioids

1-Bromocodeine

1-Chlorocodeine

1-Iodomorphine

Active opiate metabolites

Structures
Active opiate metabolites
Codeine-N-oxide Heroin-7,8-oxide Morphine-6-glucuronide 6-Monoacetylmorphine
Morphine-N-oxide Naltrexol Norcodeine Normorphine

Morphinans

Levomethorphan

Morphinan series

Structures
Other morphinans
4-chlorophenylpyridomorphinan Cyclorphan Dextrallorphan Levargorphan Levophenacylmorphan
Levomethorphan Norlevorphanol N-Methylmorphinan Oxilorphan Phenomorphan
Dextromethorphan levomethorphan Morphanol Ro4-1539 Stephodeline Xorphanol

Others

Structures
Other Morphinans
1-Nitroaknadinine 14-episinomenine 5,6-Dihydronorsalutaridine 6-Keto Nalbuphine Aknadinine
Butorphanol Cephakicine Cephasamine Cyprodime Drotebanol
Fenfangjine G Nalbuphine Sinococuline Sinomenine Tannagine

Benzomorphans

Structures
Benzomorphans
5,9 alpha-diethyl-2-hydroxybenzomorphan
(5,9-DEHB)		 8-Carboxamidocyclazocine Alazocine Anazocine Bremazocine
Butinazocine Carbazocine Cogazocine Cyclazocine Dezocine
Eptazocine Etazocine Ethylketocyclazocine Fedotozine Fluorophen
Gemazocine Ibazocine Ketazocine Metazocine Moxazocine
Pentazocine Phenazocine Quadazocine Thiazocine Tonazocine
Volazocine Zenazocine

4-Phenylpiperidines

Pethidine

Pethidines (meperidines)

Structures
Pethidines (meperidines)
4-Fluoropethidine 8-Carboxamidocyclazocine Allylnorpethidine Anileridine Benzethidine
Carperidine Difenoxin Diphenoxylate Etoxeridine Furethidine
Hydroxypethidine Morpheridine Meperidine-N-oxide Oxpheneridine Pethidine
Pethidine intermediate A Pethidine intermediate B Pethidine intermediate C Pheneridine Phenoperidine
Piminodine Properidine Sameridine

Prodines

Structures
Prodines
Allylprodine (α/β)-Meprodine Desmethylprodine (MPPP) PEPAP Prodine
Prosidol Prosidol

Ketobemidones

Structures
Ketobemidones
Acetoxyketobemidone Droxypropine Ketobemidone Methylketobemidone Propylketobemidone

Others

Structures
Other phenylpiperidines
Alvimopan Loperamide LS-115509 Picenadol

Open chain opioids

Methadone

Amidones

Structures
Amidones

Dextromethadone

Dipipanone

Isomethadone

 Levoisomethadone
Noracetylmethadol Levomethadone Methadone Methadone intermediate
Normethadone Norpipanone Phenadoxone Pipidone

Methadols

Structures
Other open chain opioids

Alphaacetylmethadol

Dimepheptanol

Levacetylmethadol

Noracetylmethadol

Moramides

Structures
Other open chain opioids

Desmethylmoramide

Dextromoramide

Levomoramide

Moramide intermediate

Racemoramide

Thiambutenes

Structures
Thiambutenes

Diethylthiambutene

Dimethylthiambutene

Ethylmethylthiambutene

Piperidylthiambutene

Thiambutene

Tipepidine

Phenalkoxams

Structures
Phenalkoxams

Dextropropoxyphene
(propoxyphene)

Dimenoxadol

Dioxaphetyl butyrate

Levopropoxyphene

Norpropoxyphene

Ampromides

Structures
Ampromides

Diampromide

Phenampromide

Propiram

Others

Structures
Other open chain opioids

Embutramide

IC-26

Isoaminile

Lefetamine

R-4066

Anilidopiperidines

Fentanyl
Structures
Anilidopiperidines
3-Allylfentanyl 3-Methylfentanyl 3-Methylthiofentanyl 4-Phenylfentanyl Alfentanil
Alphamethylacetylfentanyl Alphamethylfentanyl Alphamethylthiofentanyl Benzylfentanyl Betahydroxyfentanyl
Betahydroxythiofentanyl Betamethylfentanyl Brifentanil Carfentanil Fentanyl
Lofentanil Mirfentanil Ocfentanil Ohmefentanyl Parafluorofentanyl
Phenaridine Remifentanil Sufentanil Thenylfentanyl Thiofentanyl
Trefentanil

Oripavine derivatives

Thienorphine
Structures
Oripavine derivatives
7-PET Acetorphine Alletorphine BU-48 Buprenorphine
Cyprenorphine Dihydroetorphine Etorphine Homprenorphine 18,19-Dehydrobuprenorphine
N-cyclopropylmethylnoretorphine Nepenthone Norbuprenorphine Thevinone Thienorphine

Phenazepanes

Structures
Phenazepanes

Ethoheptazine

Meptazinol

Metheptazine

Metethoheptazine

Proheptazine

Pirinitramides

Structures
Pirinitramides

Bezitramide

Piritramide

Benzimidazoles

Structures
Benzimidazoles

Clonitazene

Etonitazene

Isotonitazene

Metonitazene

Nitazene: R = hydrogen

Indoles

Structures
Indoles

18-Methoxycoronaridine

7-Acetoxymitragynine

7-Hydroxymitragynine

Akuammidine

Akuammine

Eseroline

Hodgkinsine

Mitragynine

Pericine

Pseudoakuammigine

Beta-Amino Ketones

  • 3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one
Structures
Indoles

3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one (Beta-amine ketone 'compound 29')

Diphenylmethylpiperazines

Structures
Diphenylmethylpiperazines

BW373U86

DPI-221

DPI-287

DPI-3290

SNC-80

Opioid peptides

β-neo-endorphin

Dynorphins

Structures
Dynorphins
Big dynorphin Dynorphin A Dynorphin B

Endomorphins

  • Endomorphin-1
  • Endomorphin-2

Endorphins

  • α-Endorphin
  • β-Endorphin
  • γ-Endorphin
  • α-Neoendorphin
  • β-Neoendorphin
Structures
Dynorphins
Beta-endorphin Alpha-endorphin Gamma-endorphin α-neo-endorphin β-neo-endorphin

Enkephalins

Structures
Enkephalins
DADLE DAMGO Deltorphin Met-enkephalin Leu-enkephalin

Propeptides

Others / unknown

Structures
Other or unknown opioid peptides
Adrenorphin Amidorphin Casomorphin DALDA Deltorphin
Dermorphin DPDPE Endomorphin-1
Endomorphin-2		 Gliadorphin Morphiceptin
Nociceptin Octreotide Opiorphin Rubiscolin TRIMU 5

Others

Opioid antagonists and inverse agonists

Biased ligands

Receptor heteromer targeting ligands

Uncategorized opioids

Structures
Uncategorized opioids

Alimadol

Anilopam

Asimadoline

FE 200665

Fedotozine

MCOPPB

Nalfurafine

 Nalodeine

Nalorphine

Nalorphine dinicotinate

SoRI-9409

Combination drug formulations containing opioids

See also

References

  1. ↑ ChemIndex CAS Registry Number 3371-56-0
  2. ↑ ChemIndex CAS Registry Number 509-56-8
  3. ↑ ChemIndex CAS Registry Number 63715-94-6
  4. ↑ NCBI PubChem SID 750205
  5. ↑ chembase cbid_346222
  6. ↑ Gomes I, Fujita W, Gupta A, Saldanha SA, Saldanha AS, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA (2013). "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. Bibcode:2013PNAS..11012072G. doi:10.1073/pnas.1222044110. PMC 3718106. PMID 23818586.
  7. ↑ Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS (2011). "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. Bibcode:2011PNAS..108.5098Y. doi:10.1073/pnas.1016277108. PMC 3064379. PMID 21385944.
  • Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time." Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1739–1740
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