Alovudine

Alovudine
Clinical data
Other namesFluorothymidine
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H13FN2O4
Molar mass244.222 g·mol−1
3D model (JSmol)
SMILES
  • O=C/1NC(=O)N(\C=C\1C)[C@@H]2O[C@@H]([C@@H](F)C2)CO
InChI
  • InChI=1S/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s1 checkY
  • Key:UXCAQJAQSWSNPQ-XLPZGREQSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Alovudine (fluorothymidine) is an antiviral agent which was being developed by Medivir. It was discontinued after a Phase II trial in 2005 due to toxicity. It is a DNA polymerase inhibitor.[1]

See also

References

  1. ↑ Georgopapadakou N (January 2007). "Discontinued drugs in 2005: anti-infectives". Expert Opinion on Investigational Drugs. 16 (1): 1–10. doi:10.1517/13543784.16.1.1. PMID 17155849. S2CID 24703317.
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