OR10J5

Olfactory receptor 10J5 is a protein that in humans is encoded by the OR10J5 gene.[5]

OR10J5
Identifiers
AliasesOR10J5, OR1-28, olfactory receptor family 10 subfamily J member 5, OLFR16, MOR23
External IDsMGI: 106648 HomoloGene: 7460 GeneCards: OR10J5
Orthologs
SpeciesHumanMouse
Entrez

127385

18313

Ensembl

ENSG00000184155

ENSMUSG00000037924

UniProt

Q8NHC4

Q62007

RefSeq (mRNA)

NM_001004469

NM_008763

RefSeq (protein)

NP_001004469

NP_032789

Location (UCSC)Chr 1: 159.54 – 159.54 MbChr 1: 172.78 – 172.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

OR10J5 is a relatively narrowly-tuned receptor, meaning it responds only to a relatively small set of related odorants.[6]

Ligands include Lyral,[6] an aldehyde with a soft floral scent.

References

  1. GRCh38: Ensembl release 89: ENSG00000184155 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037924 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: OR10J5 olfactory receptor, family 10, subfamily J, member 5".
  6. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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