OR51E1

Olfactory receptor 51E1 is a protein that in humans is encoded by the OR51E1 gene.[5]

OR51E1
Identifiers
AliasesOR51E1, D-GPCR, DGPCR, GPR136, GPR164, OR51E1P, OR52A3P, POGR, PSGR2, olfactory receptor family 51 subfamily E member 1
External IDsOMIM: 611267 MGI: 3030392 HomoloGene: 17503 GeneCards: OR51E1
Orthologs
SpeciesHumanMouse
Entrez

143503

259097

Ensembl

ENSG00000180785

ENSMUSG00000070423

UniProt

Q8TCB6

Q8VGZ7

RefSeq (mRNA)

NM_152430

NM_147093

RefSeq (protein)

NP_689643

NP_667304

Location (UCSC)Chr 11: 4.64 – 4.66 MbChr 7: 102.35 – 102.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

The receptor is associated with some compounds with a "cheese" or "sour" scent note. Examples of compounds that activate OR51E1 include:

The following are in decreasing order of activity:[9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000180785 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000070423 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: OR51E1 olfactory receptor, family 51, subfamily E, member 1".
  6. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.
  7. Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC 3990440. PMID 24316890.
  8. Fujita Y, Takahashi T, Suzuki A, Kawashima K, Nara F, Koishi R (2007). "Deorphanization of Dresden G protein-coupled receptor for an odorant receptor". Journal of Receptor and Signal Transduction Research. 27 (4): 323–34. doi:10.1080/10799890701534180. PMID 17885925. S2CID 42999502.
  9. Adipietro KA, Mainland JD, Matsunami H (2012). "Functional evolution of mammalian odorant receptors". PLOS Genetics. 8 (7): e1002821. doi:10.1371/journal.pgen.1002821. PMC 3395614. PMID 22807691.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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