OR5A1

Olfactory receptor 5A1 is a protein that in humans is encoded by the OR5A1 gene.[5]

OR5A1
Identifiers
AliasesOR5A1, OR11-249, OR5A1P, OST181, olfactory receptor family 5 subfamily A member 1
External IDsMGI: 2153205 HomoloGene: 17342 GeneCards: OR5A1
Orthologs
SpeciesHumanMouse
Entrez

219982

258677

Ensembl

ENSG00000172320

ENSMUSG00000067522

UniProt

Q8NGJ0

Q8VFV2

RefSeq (mRNA)

NM_001004728

NM_146682

RefSeq (protein)

NP_001004728

NP_666893

Location (UCSC)Chr 11: 59.44 – 59.45 MbChr 19: 12.1 – 12.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Genetic differences

A single-nucleotide polymorphism in the OR5A1 receptor (rs6591536[6]) causes very significant differences in the odor perception of beta-ionone, both in sensitivity and also in subjective quality. Individuals who contain at least one G allele are sensitive to beta-ionone and perceive a pleasant floral scent, while individuals who are homozygous AA are ~100 times less sensitive and at higher concentrations perceive a pungent sour/vinegar odor instead.[7]

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000172320 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000067522 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: OR5A1 olfactory receptor, family 5, subfamily A, member 1".
  6. "rs6591536". SNPedia.
  7. Jaeger SR, McRae JF, Bava CM, Beresford MK, Hunter D, Jia Y, Chheang SL, Jin D, Peng M, Gamble JC, Atkinson KR, Axten LG, Paisley AG, Tooman L, Pineau B, Rouse SA, Newcomb RD (2013). "A Mendelian Trait for Olfactory Sensitivity Affects Odor Experience and Food Selection". Current Biology. 23 (16): 1601–1605. doi:10.1016/j.cub.2013.07.030. PMID 23910657.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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