OR5AN1

OR5AN1
Identifiers
Aliases	OR5AN1, OR11-244, olfactory receptor family 5 subfamily AN member 1
External IDs	OMIM: 615702 MGI: 3031268 HomoloGene: 45029 GeneCards: OR5AN1
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	59,371,714 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	12,262,990 bp[2]
RNA expression pattern
	n/a
	n/a
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; odorant binding; olfactory receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway; detection of chemical stimulus involved in sensory perception;
	Sources:Amigo / QuickGO
Orthologs
	390195
	258680
	ENSG00000176495
	ENSMUSG00000095640
	Q8NGI8
	n/a
	NM_001004729
	NM_146685
	NP_001004729
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 5AN1 is a protein that in humans is encoded by the OR5AN1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

References

GRCh38: Ensembl release 89: ENSG00000176495 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000095640 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: OR5AN1 olfactory receptor, family 5, subfamily AN, member 1".
Ahmed, L.; et al. (2018). "Molecular Mechanism of Activation of Human Musk Receptors OR5AN1 and OR1A1 by (R)-Muscone and Diverse Other Musk-smelling Compounds". Proc. Natl. Acad. Sci. USA. 115 (17): E3950–E3958. doi:10.1073/pnas.1713026115. PMC 5924878. PMID 29632183.

External links

OR5AN1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176495 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000095640 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OR5AN1 olfactory receptor, family 5, subfamily AN, member 1".

[Ahmed-6] Ahmed, L.; et al. (2018). "Molecular Mechanism of Activation of Human Musk Receptors OR5AN1 and OR1A1 by (R)-Muscone and Diverse Other Musk-smelling Compounds". Proc. Natl. Acad. Sci. USA. 115 (17): E3950–E3958. doi:10.1073/pnas.1713026115. PMC 5924878. PMID 29632183.

OR5AN1

Ligands

See also

References

Further reading

External links