OR1B1

OR1B1
Identifiers
Aliases	OR1B1, OR9-26, OR9-B, olfactory receptor family 1 subfamily B member 1 (gene/pseudogene), olfactory receptor family 1 subfamily B member 1
External IDs	MGI: 3030196 HomoloGene: 17479 GeneCards: OR1B1
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	122,629,573 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	37,007,922 bp[2]
RNA expression pattern
	Top expressed in
	placenta; ; endometrium; ; cervix; ; lymph node; ; right lung; ; gallbladder; ; superior frontal gyrus; ; canal of the cervix;
	Top expressed in
	spermatid; ; testicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; transmembrane signaling receptor activity; olfactory receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; detection of chemical stimulus involved in sensory perception; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	347169
	259053
	ENSG00000280094
	ENSMUSG00000075377
	Q8NGR6
	Q8VGV7
	NM_001004450
	NM_147051
	NP_001004450
	NP_667262
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 1B1 is a protein that in humans is encoded by the OR1B1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

As of 2015, OR1B1 was an orphan receptor, meaning that no odorants have been identified which bind to it.[6]

References

GRCh38: Ensembl release 89: ENSG00000280094 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000075377 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: OR1B1 olfactory receptor, family 1, subfamily B, member 1".
de March CA, Ryu S, Sicard G, Moon C, Golebiowski J (September 2015). "Structure–odour relationships reviewed in the postgenomic era". Flavour and Fragrance Journal. 30 (5): 342–361. doi:10.1002/ffj.3249.

External links

OR1B1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000280094 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000075377 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OR1B1 olfactory receptor, family 1, subfamily B, member 1".

[6] March CA, Ryu S, Sicard G, Moon C, Golebiowski J (September 2015). "Structure–odour relationships reviewed in the postgenomic era". Flavour and Fragrance Journal. 30 (5): 342–361. doi:10.1002/ffj.3249.

OR1B1

Ligands

See also

References

Further reading

External links