OR6A2

Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene.[5] It is Class II (tetrapod-specific) olfactory receptor and a rhodopsin-like receptor.

OR6A2
Identifiers
AliasesOR6A2, I7, OR11-55, OR6A1, OR6A2P, olfactory receptor family 6 subfamily A member 2
External IDsOMIM: 608495 MGI: 97432 HomoloGene: 2743 GeneCards: OR6A2
Orthologs
SpeciesHumanMouse
Entrez

8590

18317

Ensembl

ENSG00000184933

ENSMUSG00000070417

UniProt

O95222

n/a

RefSeq (mRNA)

NM_003696

NM_010983

RefSeq (protein)

NP_003687

n/a

Location (UCSC)Chr 11: 6.79 – 6.8 MbChr 7: 106.59 – 106.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals.[5]

Clinical significance

Variation in the OR6A2 gene has been identified as a likely cause of why some people enjoy the smell and taste of coriander (also known as cilantro)[6] while others have exactly the opposite reaction to the point of repulsion. Depending on ancestry, somewhere between 3% and 21% of the population associate it with unpleasant taste, including a combination of soap and vomit, or say that it is similar to the foul smelling odor emitted by stinkbugs. This is due to the presence of aldehyde chemicals, which are present in soap, various detergents, coriander, several species of stinkbugs and cinnamon.[7]

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000184933 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000070417 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2".
  6. Eriksson N; Wu S; Chuong BD; et al. (29 November 2012). "A genetic variant near olfactory receptor genes influences cilantro preference". Flavour. 1. arXiv:1209.2096. doi:10.1186/2044-7248-1-22. S2CID 199627.
  7. Callaway E (September 2012). "Soapy taste of coriander linked to genetic variants". Nature. doi:10.1038/nature.2012.11398. S2CID 87980895.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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