OR2W1

OR2W1
Identifiers
Aliases	OR2W1, hs6M1-15, olfactory receptor family 2 subfamily W member 1
External IDs	MGI: 3030097 HomoloGene: 12791 GeneCards: OR2W1
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	29,045,175 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	21,320,466 bp[2]
RNA expression pattern
	Top expressed in
	sural nerve;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; olfactory receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	26692
	18341
ENSG00000204704; ENSG00000226463; ENSG00000206525; ENSG00000228977; ENSG00000228652;
	ENSG00000229328; ENSG00000227639; ENSG00000234101
	ENSMUSG00000071522
	Q9Y3N9
	Q7TQT8
	NM_030903
	NM_010984
	NP_112165
	NP_035114
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 2W1 is a protein that in humans is encoded by the OR2W1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

Out of 10 human ORs studied, OR2W1 was the most broadly tuned, meaning it responds to the greatest variety of different odorant molecules.[6]

Ligands, in decreasing order of sensitivity:[6]

References

ENSG00000226463, ENSG00000206525, ENSG00000228977, ENSG00000228652, ENSG00000229328, ENSG00000227639, ENSG00000234101 GRCh38: Ensembl release 89: ENSG00000204704, ENSG00000226463, ENSG00000206525, ENSG00000228977, ENSG00000228652, ENSG00000229328, ENSG00000227639, ENSG00000234101 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000071522 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: OR2W1 olfactory receptor, family 2, subfamily W, member 1".
Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.
Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.

External links

OR2W1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] ENSG00000226463, ENSG00000206525, ENSG00000228977, ENSG00000228652, ENSG00000229328, ENSG00000227639, ENSG00000234101 GRCh38: Ensembl release 89: ENSG00000204704, ENSG00000226463, ENSG00000206525, ENSG00000228977, ENSG00000228652, ENSG00000229328, ENSG00000227639, ENSG00000234101 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071522 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OR2W1 olfactory receptor, family 2, subfamily W, member 1".

[pmid19261596-6] Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.

[pmid24695519-7] Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.

OR2W1

Ligands

See also

References

Further reading

External links