OR52D1

OR52D1
Identifiers
Aliases	OR52D1, OR11-43, olfactory receptor family 52 subfamily D member 1, olfactory receptor family 52 subfamily D member 1 (gene/pseudogene)
External IDs	MGI: 3030480 HomoloGene: 17481 GeneCards: OR52D1
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	5,489,749 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	103,758,973 bp[2]
RNA expression pattern
	Top expressed in
	sural nerve; ; Achilles tendon;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; olfactory receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	390066
	259058
	ENSG00000181609
	ENSMUSG00000073931
	Q9H346
	Q8VGW2
	NM_001005163
	NM_147056
	NP_001005163
	NP_667267
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 52D1 is a protein that in humans is encoded by the OR52D1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

Compared to other olfactory receptors such as OR1G1, OR52D1 has a more narrow/specific range of ligands.[6]

Agonists:

Methyl octanoate[6]
"Better activated by acids, aldehydes, ketones and esters than alcohols or pyrazines"[6]

References

GRCh38: Ensembl release 89: ENSG00000181609 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000073931 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: OR52D1 olfactory receptor, family 52, subfamily D, member 1".
Sanz G, Schlegel C, Pernollet JC, Briand L (January 2005). "Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism". Chemical Senses. 30 (1): 69–80. doi:10.1093/chemse/bji002. PMID 15647465.

External links

OR52D1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181609 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000073931 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: OR52D1 olfactory receptor, family 52, subfamily D, member 1".

[Sanz2005-6] Sanz G, Schlegel C, Pernollet JC, Briand L (January 2005). "Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism". Chemical Senses. 30 (1): 69–80. doi:10.1093/chemse/bji002. PMID 15647465.

OR52D1

Ligands

See also

References

Further reading

External links