α-PCYP

α-PCyP is a stimulant drug of the cathinone class that has been sold online as a designer drug. In a series of alpha-substituted pyrrolidinyl cathinone derivatives developed in 2015, the alpha-cyclopentyl derivative was found to have around the same potency in vitro as an inhibitor of the dopamine transporter as the alpha-propyl derivative α-PVP, while the alpha-cyclohexyl derivative α-PCyP was around twice as strong.[1][2][3]

Not to be confused with PCPy.
α-PCyP
Legal status
Legal status
Identifiers
IUPAC name
  • 2-cyclohexyl-1-phenyl-2-(pyrrolidin-1-yl)ethanone
CAS Number
PubChem CID
UNII
Chemical and physical data
FormulaC18H25NO
Molar mass271.404 g·mol−1
3D model (JSmol)
SMILES
  • O=C(C(C1CCCCC1)N2CCCC2)c3ccccc3
InChI
  • InChI=1S/C18H25NO/c20-18(16-11-5-2-6-12-16)17(19-13-7-8-14-19)15-9-3-1-4-10-15/h2,5-6,11-12,15,17H,1,3-4,7-10,13-14H2
  • Key:FKEHRWJWTWDTDB-UHFFFAOYSA-N

See also

References
  1. Kolanos R, Sakloth F, Jain AD, Partilla JS, Baumann MH, Glennon RA (October 2015). "Structural Modification of the Designer Stimulant α-Pyrrolidinovalerophenone (α-PVP) Influences Potency at Dopamine Transporters". ACS Chemical Neuroscience. 6 (10): 1726–31. doi:10.1021/acschemneuro.5b00160. PMC 5349767. PMID 26217965.
  2. Glennon RA, Dukat M (2016). "Structure-Activity Relationships of Synthetic Cathinones". Current Topics in Behavioral Neurosciences. 32: 19–47. doi:10.1007/7854_2016_41. ISBN 978-3-319-52442-9. PMC 5818155. PMID 27830576.
  3. Baumann MH, Walters HM, Niello M, Sitte HH (2018). "Neuropharmacology of Synthetic Cathinones". Handbook of Experimental Pharmacology. 252: 113–142. doi:10.1007/164_2018_178. ISBN 978-3-030-10560-0. PMC 7257813. PMID 30406443.
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