Polyestradiol phosphate/medroxyprogesterone acetate
Combination of | |
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Polyestradiol phosphate | Estrogen |
Medroxyprogesterone acetate | Progestogen |
Clinical data | |
Other names | PEP/MPA |
Routes of administration | Intramuscular injection |
Polyestradiol phosphate/medroxyprogesterone acetate (PEP/MPA) is a combination of polyestradiol phosphate (PEP), an estrogen, and medroxyprogesterone acetate (MPA), a progestin, which was studied in the 1960s as a long-lasting combined injectable contraceptive for women but was never marketed.[1][2][3] It was administered by intramuscular injection once every 3 months and contained 40 mg PEP and 150 mg MPA.[1][2][3] The combination was studied in a sample of 99 premenopausal women and was found to be effective in preventing pregnancy, but caused menstrual irregularities similar to those of MPA alone as a progestogen-only injectable contraceptive.[1][2][3] PEP was included in the formulation to prevent estrogen deficiency and reduce menstrual abnormalities caused by MPA during long-term contraceptive therapy.[2]
See also
References
- 1 2 3 Joseph William Goldzieher; Kenneth Fotherby (1994). Pharmacology of the contraceptive steroids. Raven Press. p. 154. ISBN 978-0-7817-0097-9.
- 1 2 3 4 Zañartu J, Rice-Wray E, Goldzieher JW (October 1966). "Fertility control with long-acting injectable steroids. A preliminary report". Obstet Gynecol. 28 (4): 513–5. PMID 5925038.
- 1 2 3 Harry Beckman (1967). The Year Book of Drug Therapy. Year Book Publishers.
Progestogens (and progestins) |
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Antiprogestogens |
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Estrogen receptor modulators | |||||||
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ER |
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GPER |
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Progesterone receptor modulators | |||||||
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PR |
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mPR (PAQR) |
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