RU-24,969

RU-24,969
Identifiers
IUPAC name
  • 5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H16N2O
Molar mass228.295 g·mol−1
3D model (JSmol)
SMILES
  • c3cc(OC)cc1c3[nH]cc1C=2CCNCC=2
InChI
  • InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3 ☒N
  • Key:KRVMLPUDAOWOGN-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

RU-24,969 is a drug and research chemical widely used in scientific studies. It is a selective agonist at the 5-HT1A and 5-HT1B receptors, with preference for the latter.[1] As with other 5-HT1B agonists such as CP-94,253, RU-24,969 has been found to increase the reinforcing properties of cocaine, suggesting a role for 5-HT1B receptors in cocaine addiction.[2]

See also

References

  1. ↑ Doods HN, Kalkman HO, De Jonge A, Thoolen MJ, Wilffert B, Timmermans PB, Van Zwieten PA (1985). "Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity". Eur J Pharmacol. 112 (3): 363–370. doi:10.1016/0014-2999(85)90782-4. PMID 3160596.
  2. ↑ Parsons LH, Weiss F, Koob GF (December 1998). "Serotonin1B receptor stimulation enhances cocaine reinforcement". Journal of Neuroscience. 18 (23): 10078–89. doi:10.1523/JNEUROSCI.18-23-10078.1998. PMC 6793270. PMID 9822762.


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