Alosetron

Alosetron
Names
Pronunciational oh’ se tron
Trade namesLotronex
IUPAC name
  • 5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one
Clinical data
Drug class5-HT3 receptor blocker[1]
Main usesDiarrhea-predominant irritable bowel syndrome (IBS) in women[1]
Side effectsConstipation, abdominal pain, nausea[2]
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • US: B (No risk in non-human studies)
    Routes of
    use    		By mouth (tablets)
    External links
    AHFS/Drugs.comMonograph
    MedlinePlusa601230
    Legal
    Legal status
    Pharmacokinetics
    Bioavailability50–60%
    Protein binding82%
    MetabolismLiver (including CYP2C9, CYP3A4 and CYP1A2)
    Elimination half-life1.5–1.7 hours
    ExcretionRenal 73%, faecal 24%
    Chemical and physical data
    FormulaC17H18N4O
    Molar mass294.358 g·mol−1
    3D model (JSmol)
    SMILES
    • Cc1nc[nH]c1CN2CCc4c(C2=O)c3ccccc3n4C
    InChI
    • InChI=1S/C17H18N4O/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2/h3-6,10H,7-9H2,1-2H3,(H,18,19) checkY
    • Key:JSWZEAMFRNKZNL-UHFFFAOYSA-N checkY

    Alosetron, sold under the brand name Lotronex among others, is a medication used for diarrhea-predominant irritable bowel syndrome (IBS) in women.[1] It should only be used in those with severe disease who cannot be managed with other treatments.[3] It is taken by mouth.[3]

    Common side effects include constipation, abdominal pain, and nausea.[2] Other side effects may include bowel obstruction and ischemic colitis.[2] Safety in pregnancy is unclear.[2] It is a 5-HT3 receptor blocker.[1]

    Alosetron was patented in 1987 and came into medical use in the 1990s.[4][1] It was temporarily withdrawn in 2000 due to isssues with constipation but was reintroduced in 2002.[1] It is available as a generic medication.[5] In the United States a month costs about 240 USD as of 2022.[5]

    Medical uses

    Alosetron is indicated only for women with severe diarrhea-predominant irritable bowel syndrome (IBS-D) who have:

    • chronic IBS symptoms (generally lasting 6 months or longer),
    • had anatomic or biochemical abnormalities of the gastrointestinal tract excluded, and
    • not responded adequately to conventional therapy.

    Severe IBS-D includes: diarrhea and 1 or more of the following:

    • frequent and severe abdominal pain/discomfort,
    • frequent bowel urgency or fecal incontinence,
    • disability or restriction of daily activities due to IBS.[6]

    Efficacy

    The phase III trial for approval was published in 2000 as an industry-funded randomised, placebo-controlled trial (PCT). Its authors found 1 mg alosetron, taken orally twice daily for 12 weeks, was associated with a 12% (CI 4.7-19.2) improvement in relief from abdominal pain and discomfort associated with diarrhoea-predominant patients.[7]

    The FDA Medical Officer's Review, dated November 4, 1999, noted: “Patients considered by investigators to fit the diarrhea-predominant subtype had at baseline… stool consistency values that were neither loose nor watery”.[8] The FDA's Gastrointestinal Drugs Advisory Committee referred to the drug's efficacy as "modest", highlighting that the placebo brought relief on the primary outcome measure to 40–50% of women.[9]

    Dosage

    It is generally used at 0.5 mg twice daily, which can be increased to 1 mg twice daily.[1]

    Contraindications

    Lotronex's prescribing information brochure states that alosetron should not be initiated in patients with constipation. Other contraindications are: history of chronic or severe constipation or sequelae from constipation; intestinal obstruction, stricture, toxic megacolon, gastrointestinal perforation, and/or adhesions, ischemic colitis, impaired intestinal circulation, thrombophlebitis, or hypercoagulable state; Crohn's disease or ulcerative colitis; diverticulitis; severe hepatic impairment. Concomitant use of fluvoxamine is also contraindicated.[6]

    Side effects

    Alosetron was withdrawn in 2000 following the association of alosetron with serious life-threatening gastrointestinal adverse effects. The cumulative incidence of ischaemic colitis was 2 in 1000, while serious complications arising from constipation (obstruction, perforation, impaction, toxic megacolon, secondary colonic ischaemia, death) was 1 in 1000.[6] A 1999 review performed by FDA medical officer John Senior, indicated that 27% of patients experienced constipation.[10] The phase III trial reported constipation occurred in 30% and 3% of patients in the alosetron and placebo groups, respectively. It was cited as the most important reason for patients dropping out of the study.[7]

    Mechanism of action

    Alosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract. While being a 5-HT3 antagonist like ondansetron, it is not classified or approved as an antiemetic. Since stimulation of 5-HT3 receptors is positively correlated with gastrointestinal motility, alosetron's 5-HT3 antagonism slows the movement of fecal matter through the large intestine, increasing the extent to which water is absorbed, and decreasing the moisture and volume of the remaining waste products.[6]

    History

    Alosetron was originally approved by the U.S. Food and Drug Administration (FDA) on February 9, 2000,[11] after a seven-month review.[12] At the time of the initial approval U.S. Food and Drug Administration (FDA) reviewers found that alosetron improved symptoms in 10% to 20% of patients.[13]

    Shipment to pharmacies started in March, 2000. On July 17, a health professional filed a report with the FDA on the death of a 50-year-old woman who suffered mesenteric ischemia. The report identified alosetron as the "primary suspect" in the death.[10]

    Alosetron was withdrawn from the market voluntarily by GlaxoWellcome on November 28, 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, including 5 deaths and additional bowel surgeries.[12] The FDA said it had reports of 49 cases of ischemic colitis and 21 cases of "severe constipation" and that ten of the 70 patients underwent surgeries and 34 others were examined at hospitals and released without surgery. Through November 17, 2000, pharmacists had filled 474,115 prescriptions for alosetron.[12] Severe adverse events continued to be reported, with a final total of 84 instances of ischaemic colitis, 113 of severe constipation, 143 admissions to hospital, and 7 deaths.[14]

    Patient advocacy groups, most notably the Lotronex Action Group and the International Foundation for Functional Gastrointestinal Disorders (IFFGD) lobbied for the drug's return. Public Citizen Health Research Group, another patient advocacy group, opposed the reintroduction.[15][9]

    On June 7, 2002, the FDA announced the approval of a supplemental New Drug Application (sNDA) that allows restricted marketing of Lotronex (alosetron hydrochloride), to treat only women with severe diarrhea-predominant irritable bowel syndrome (IBS).[6][16][17] The strict prescribing guidelines initially introduced in 2002 were relaxed slightly in 2016, enabling electronic prescriptions among other benefits.

    It is not known whether alosetron has been filed for registration in the EU.

    GSK sold Lotronex to the Californian corporation Prometheus in late 2007.[18]

    Since 2015, generic versions of alosetron have been available in the US, sold by a number of different companies including Actavis Pharma Company, Prometheus Laboratories and Sebela Pharmaceuticals Inc

    Criticism of the FDA

    In 2001, the editor of the renowned medical journal The Lancet, Richard Horton, criticized the FDA's handling of alosetron in an unusually sharp language.[19] Horton argued that the treatment of a non-fatal condition did not justify the use of a drug with potentially lethal side effects, and that the FDA should have revoked the approval for alosetron sooner when postmarketing surveillance revealed that many patients had suffered constipation necessitating surgical intervention and ischaemic colitis. He asserted that FDA officials were improperly motivated to maintain and reinstate the approval for alosetron because of the extent to which the FDA's Center for Drug Evaluation and Research is funded by user fees paid by pharmaceutical manufacturers, and that the reinstatement of alosetron was negotiated in confidential meetings with representatives of GlaxoSmithKline.

    An article published in the British Medical Journal (BMJ) noted: "By allowing the marketing of alosetron, a drug that poses a serious and significant public health concern according to its own terms, the FDA failed in its mission."[20] Others have argued that the approval process of Lotronex was an example of regulatory capture.[9]

    References

    1. 1 2 3 4 5 6 7 "Serotonin 5-HT3 Receptor Antagonists". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 8 May 2021. Retrieved 14 January 2022.
    2. 1 2 3 4 "DailyMed - ALOSETRON HYDROCHLORIDE tablet". dailymed.nlm.nih.gov. Archived from the original on 21 April 2021. Retrieved 14 January 2022.
    3. 1 2 "Alosetron Monograph for Professionals". Drugs.com. Archived from the original on 25 January 2021. Retrieved 14 January 2022.
    4. ↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 448. ISBN 9783527607495. Archived from the original on 2021-09-30. Retrieved 2021-10-11.
    5. 1 2 "Alosetron Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 24 January 2016. Retrieved 14 January 2022.
    6. 1 2 3 4 5 "Lotronex (alosetron hydrochloride) Tablets. Full Prescribing Information" (PDF). Prometheus Laboratories Inc., 9410 Carroll Park Drive, San Diego, CA 92121. Archived from the original (PDF) on 22 February 2016. Retrieved 14 February 2016.
    7. 1 2 Camilleri M, Northcutt AR, Kong S, Dukes GE, McSorley D, Mangel AW (March 2000). "Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial". Lancet. 355 (9209): 1035–40. doi:10.1016/S0140-6736(00)02033-X. PMID 10744088. S2CID 31290668.
    8. ↑ Barbehenn E, Lurie P, Wolfe SM (December 2000). "Alosetron for irritable bowel syndrome". Lancet. 356 (9246): 2009–10. doi:10.1016/S0140-6736(05)72978-0. PMID 11130544. S2CID 30340322. Archived from the original on 2021-11-04. Retrieved 2021-10-11.
    9. 1 2 3 Moynihan R (September 2002). "Alosetron: a case study in regulatory capture, or a victory for patients' rights?". BMJ. 325 (7364): 592–5. doi:10.1136/bmj.325.7364.592. PMC 1124108. PMID 12228140.
    10. 1 2 Willman D (2 November 2000). "FDA Minimized Issue of Lotronex's Safety". The Los Angeles Times. Archived from the original on 13 December 2011. Retrieved 11 December 2012.
    11. ↑ U.S. Food and Drug Administration. "Drug Details". Archived from the original on 13 August 2014. Retrieved 11 December 2012.
    12. 1 2 3 Willman D (29 November 2000). "Drug Lotronex Pulled Over Safety Fears". The Los Angeles Times. Archived from the original on 13 December 2011. Retrieved 11 December 2012.
    13. ↑ Willman D (20 December 2000). "Officer Foresaw Deadly Effects". The Los Angeles Times. Archived from the original on 13 December 2011. Retrieved 11 December 2012.
    14. ↑ Center for Drug Evaluation and Research (23 April 2002). "Gastrointestinal Drugs Advisory Committee and Drug Safety and Risk Management Subcommittee of the Advisory Committee for Pharmaceutical Science" (PDF). U.S. Food and Drug Administration. Archived (PDF) from the original on 19 August 2011. Retrieved 11 December 2012.
    15. ↑ Grady D (23 April 2002). "Appeals Prompt U.S. Agency to Consider Allowing Sales of Diarrhea Drug Linked to Deaths". The New York Times. Archived from the original on 13 July 2012. Retrieved 11 December 2012.
    16. ↑ Pollack A (2006-03-09). "F.D.A. Panel Recommends M.S. Drug Despite Lethal Risk". The New York Times. Archived from the original on 2016-01-11. Retrieved 2008-03-13.
    17. ↑ Grady D (8 June 2002). "U.S. Lets Drug Tied to Deaths Back on Market". The New York Times. Archived from the original on 5 April 2013. Retrieved 11 December 2012.
    18. ↑ Prometheus Laboratories Inc. Press Release of 7 November 2007. Archived 2012-07-14 at archive.today Retrieved on 27 August 2008.
    19. ↑ Horton R (May 2001). "Lotronex and the FDA: a fatal erosion of integrity". Lancet. 357 (9268): 1544–5. doi:10.1016/S0140-6736(00)04776-0. PMID 11377636. S2CID 10886502.
    20. ↑ Lièvre M (September 2002). "Alosetron for irritable bowel syndrome". BMJ. 325 (7364): 555–6. doi:10.1136/bmj.325.7364.555. PMC 1124090. PMID 12228116.
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