ID2

ID2
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معرفات بنك بيانات البروتين
	4AYA
المعرفات
الأسماء المستعارة	ID2, GIG8, A, H, bHLHb26, inhibitor of DNA binding 2, HLH protein, inhibitor of DNA binding 2
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 600386 MGI: MGI:96397 HomoloGene: 1632 GeneCards: 3398
علم الوجود الجيني
الوظيفة الجزيئية	• protein dimerization activity; • transmembrane transporter binding; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • ‏GO:0001131، ‏GO:0001151، ‏GO:0001130، ‏GO:0001204 DNA-binding transcription factor activity; • transcription factor binding;
المكونات الخلوية	• نواة; • عصارة خلوية; • سيتوبلازم; • ‏GO:0009327 protein-containing complex;
العمليات الحيوية	• regulation of G1/S transition of mitotic cell cycle; • rhythmic process; • negative regulation of DNA-binding transcription factor activity; • ‏GO:0009373 ضبط نسخ الدنا; • positive regulation of transcription involved in G1/S transition of mitotic cell cycle; • نمو متعدد الخلايا; • ‏GO:0045996 negative regulation of transcription, DNA-templated; • نسخ الدنا; • ‏GO:1901227 negative regulation of transcription by RNA polymerase II; • metanephros development; • natural killer cell differentiation; • thigmotaxis; • leukocyte differentiation; • membranous septum morphogenesis; • bundle of His development; • نماء القلب; • نظم يوماوي; • adult locomotory behavior; • entrainment of circadian clock; • ‏GO:1901313 positive regulation of gene expression; • negative regulation of gene expression; • oligodendrocyte development; • regulation of lipid metabolic process; • olfactory bulb development; • circadian regulation of gene expression; • mammary gland epithelial cell proliferation; • regulation of circadian rhythm; • entrainment of circadian clock by photoperiod; • enucleate erythrocyte differentiation; • negative regulation of DNA binding; • locomotor rhythm; • negative regulation of B cell differentiation; • positive regulation of fat cell differentiation; • positive regulation of erythrocyte differentiation; • positive regulation of macrophage differentiation; • negative regulation of neuron differentiation; • negative regulation of osteoblast differentiation; • positive regulation of blood pressure; • ‏GO:0060469، ‏GO:0009371 positive regulation of transcription, DNA-templated; • cell development; • cell maturation; • Peyer's patch development; • embryonic digestive tract morphogenesis; • positive regulation of smooth muscle cell proliferation; • neuron fate commitment; • cell morphogenesis involved in neuron differentiation; • positive regulation of astrocyte differentiation; • negative regulation of oligodendrocyte differentiation; • adipose tissue development; • mammary gland alveolus development; • epithelial cell differentiation involved in mammary gland alveolus development; • endodermal digestive tract morphogenesis; • cellular response to lithium ion; • cellular senescence; • negative regulation of neural precursor cell proliferation; • neuron differentiation; • regulation of cell cycle;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q02363
	P41136
	NM_002166
	NM_010496
	NP_002157
	NP_034626
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

ID2‏ (Inhibitor of DNA binding 2) هوَ بروتين يُشَفر بواسطة جين ID2 في الإنسان.[1]

المراجع

"Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts"، J Biol Chem، 269 (3): 2139–45، فبراير 1994، PMID 8294468.

قراءة متعمقة

"A human Id-like helix-loop-helix protein expressed during early development"، Proc. Natl. Acad. Sci. U.S.A.، 89 (4): 1512–6، 1992، doi:10.1073/pnas.89.4.1512، PMC 48481، PMID 1741406.
"The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein"، Genes Dev.، 8 (11): 1270–84، 1994، doi:10.1101/gad.8.11.1270، PMID 7926730.
"Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides"، Gene، 138 (1–2): 171–4، 1994، doi:10.1016/0378-1119(94)90802-8، PMID 8125298.
"Two distinct cDNA sequences encoding the human helix-loop-helix protein Id2"، Gene، 133 (2): 305–6، 1993، doi:10.1016/0378-1119(93)90658-P، PMID 8224921.
"Chromosomal assignment of human ID1 and ID2 genes"، Genomics، 30 (2): 385–7، 1996، doi:10.1006/geno.1995.0037، PMID 8586447.
"Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins"، Mol. Cell. Biol.، 16 (6): 2570–8، 1996، PMC 231247، PMID 8649364.
"Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors"، EMBO J.، 16 (2): 332–42، 1997، doi:10.1093/emboj/16.2.332، PMC 1169639، PMID 9029153.
"Differential interactions of Id proteins with basic-helix-loop-helix transcription factors"، J. Biol. Chem.، 272 (32): 19785–93، 1997، doi:10.1074/jbc.272.32.19785، PMID 9242638.
"Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library"، Gene، 200 (1–2): 149–56، 1997، doi:10.1016/S0378-1119(97)00411-3، PMID 9373149.
"Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors"، EMBO J.، 18 (4): 968–76، 1999، doi:10.1093/emboj/18.4.968، PMC 1171189، PMID 10022839.
"Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2"، Nature، 397 (6721): 702–6، 1999، doi:10.1038/17812، PMID 10067894.
"Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain"، Exp. Cell Res.، 252 (1): 224–35، 1999، doi:10.1006/excr.1999.4609، PMID 10502414.
"Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes"، Biochem. J.، 344 Pt 3 (Pt 3): 873–80، 2000، doi:10.1042/0264-6021:3440873، PMC 1220711، PMID 10585876.
"A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function"، Biochem. Biophys. Res. Commun.، 273 (3): 1042–7، 2000، doi:10.1006/bbrc.2000.3055، PMID 10891368.
"Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins"، Nature، 407 (6804): 592–8، 2000، doi:10.1038/35036504، PMID 11034201.
"Id Helix-Loop-Helix Proteins Antagonize Pax Transcription Factor Activity by Inhibiting DNA Binding"، Mol. Cell. Biol.، 21 (2): 524–33، 2001، doi:10.1128/MCB.21.2.524-533.2001، PMC 86614، PMID 11134340.
"A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development"، Neuron، 29 (3): 603–14، 2001، doi:10.1016/S0896-6273(01)00237-9، PMID 11301021.
"Characterization of a basic helix-loop-helix protein, ABF-1: nuclear localization, transcriptional properties, and interaction with Id-2"، DNA Cell Biol.، 20 (8): 465–71، 2001، doi:10.1089/104454901316976091، PMID 11560778.
"Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs"، Genome Res.، 11 (10): 1758–65، 2001، doi:10.1101/gr.180101، PMC 311163، PMID 11591653.

بوابة علم الأحياء الخلوي والجزيئي
بوابة طب
بوابة الكيمياء الحيوية

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[pmid8294468-1] "Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts"، J Biol Chem، 269 (3): 2139–45، فبراير 1994، PMID 8294468.

التصنيفات الطبية	OMIM ID: 600386
المعرفات الخارجية	Ensembl Transcript ID: ENST00000472142, ENST00000234091, ENST00000331129, ENST00000396290