Atenolol/chlorthalidone

Atenolol/chlorthalidone, also known as co-tenidone, is a combination medication used to treat high blood pressure.[2][3] It is made up of atenolol, a beta-blocker and chlortalidone, a diuretic.[4] It is not recommended as an initial treatment but may be used in those who are taking atenolol and chlortalidone individually.[5] It is taken by mouth.[2]

Atenolol/chlorthalidone
Combination of
AtenololBeta blocker
ChlortalidoneDiuretic
Clinical data
Trade namesTenoretic, Tenoret, others
AHFS/Drugs.comFDA Professional Drug Information
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
KEGG

Common side effects include gastrointestinal upset and gout.[3] Serious side effects may include liver problems, pancreatitis, and psychosis.[3] Use is not recommended during pregnancy.[3] Use during breastfeeding may harm the baby.[2] Atenolol works by blocking β1-adrenergic receptors in the heart, thus decreasing the heart rate and workload.[3] Chlorthalidone works by increasing the amount of sodium lost by the kidneys.[2]

The combination was approved for medical use in the United States in 1984.[4] It is available as a generic medication.[3] In 2017, it was the 295th most commonly prescribed medication in the United States, with more than one million prescriptions.[6][7]

References
  1. "Tenoret 50 mg/12.5 mg film coated tablets - Summary of Product Characteristics (SmPC)". (emc). 29 November 2019. Retrieved 4 May 2020.
  2. "DailyMed - atenolol and chlorthalidone tablet". dailymed.nlm.nih.gov. Retrieved 18 April 2019.
  3. British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 153. ISBN 9780857113382.
  4. "Atenolol and Chlorthalidone Tablets - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 18 April 2019.
  5. "Atenolol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 18 April 2019.
  6. "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  7. "Atenolol; Chlorthalidone - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.


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