Thialbarbital

Thialbarbital
Clinical data
Other namesKemithal, 5-(1-cyclohex-2-enyl)-5-prop-2-enyl-2-sulfanylidene-1,3-diazinane-4,6-dione
ATC code
  • none
Legal status
Legal status
Identifiers
IUPAC name
  • 5-allyl-5-cyclohex-2-en-1-yl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
ECHA InfoCard100.006.720
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Chemical and physical data
FormulaC13H16N2O2S
Molar mass264.34 g·mol−1
3D model (JSmol)
SMILES
  • O=C1NC(=S)NC(=O)C1(C2/C=C\CCC2)C\C=C
InChI
  • InChI=1S/C13H16N2O2S/c1-2-8-13(9-6-4-3-5-7-9)10(16)14-12(18)15-11(13)17/h2,4,6,9H,1,3,5,7-8H2,(H2,14,15,16,17,18) checkY
  • Key:PXLVRFQEBVNJOH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Thialbarbital (Intranarcon) is a barbiturate derivative invented in the 1960s. It has sedative effects, and was used primarily for induction in surgical anaesthesia.[1] Thialbarbital is short acting and has less of a tendency to induce respiratory depression than other barbiturate derivatives such as pentobarbital.[2]

Synthesis

Thialbarbital synthesis: Volwiler, Tabern, U.S. Patent 2,153,730 (1939 to Abbott)

See also

References

  1. Golovchinsky VB, Plehotkina SI (July 1971). "Difference in the sensitivity of the cerebral cortex and midbrain reticular formation to the action of diethylether and thialbarbital". Brain Research. 30 (1): 37–47. doi:10.1016/0006-8993(71)90004-7. PMID 5092630.
  2. Bercovitz AB, Godke RA, Biellier HV, Short CE (March 1975). "Surgical anesthesia in turkeys with thialbarbital sodium". American Journal of Veterinary Research. 36 (3): 301–2. PMID 1115429.


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