SB-205384

SB-205384
Legal status
Legal status
Identifiers
IUPAC name
  • But-2-ynyl 4-amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[3,2-e]pyridine-3-carboxylate
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H18N2O3S
Molar mass330.40 g·mol−1
3D model (JSmol)
SMILES
  • CC#CCOC(=O)c1c(C)nc2sc3CC(O)CCc3c2c1N
InChI
  • InChI=1S/C17H18N2O3S/c1-3-4-7-22-17(21)13-9(2)19-16-14(15(13)18)11-6-5-10(20)8-12(11)23-16/h10,20H,5-8H2,1-2H3,(H2,18,19) ☒N
  • Key:JDTZAGLGBRRCJT-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

SB-205384 is an anxiolytic drug. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.

SB-205384 is a GABAA positive allosteric modulator, which binds preferentially to α3, α5, and α6 subunit containing subtypes.[1][2] It has a novel mechanism of action, prolonging the duration of GABA-mediated chloride flux but without increasing the intensity of the response, and this may give it an unusual pharmacological profile,[3] with tests showing that it alters the firing of some populations of neurons while leaving others unaffected.[4] Animal studies have shown it to produce both anxiolytic and anti-aggressive effects, but with little sedation or other behavioural changes.[5][6]

References

  1. ↑ Heidelberg LS, Warren JW, Fisher JL (October 2013). "SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits". The Journal of Pharmacology and Experimental Therapeutics. 347 (1): 235–41. doi:10.1124/jpet.113.207324. PMC 3781410. PMID 23902941.
  2. ↑ Meadows HJ, Kumar CS, Pritchett DB, Blackburn TP, Benham CD (March 1998). "SB-205384: a GABA(A) receptor modulator with novel mechanism of action that shows subunit selectivity". British Journal of Pharmacology. 123 (6): 1253–9. doi:10.1038/sj.bjp.0701721. PMC 1565273. PMID 9559912.
  3. ↑ Meadows HJ, Harries MH, Thompson M, Benham CD (August 1997). "Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum". British Journal of Pharmacology. 121 (7): 1334–8. doi:10.1038/sj.bjp.0701251. PMC 1564816. PMID 9257911.
  4. ↑ Ing T, Poulter MO (February 2007). "Diversity of GABA(A) receptor synaptic currents on individual pyramidal cortical neurons". The European Journal of Neuroscience. 25 (3): 723–34. doi:10.1111/j.1460-9568.2007.05331.x. PMID 17313570. S2CID 9361003.
  5. ↑ Navarro JF, Burón E, Martín-López M (February 2006). "Anxiolytic-like activity of SB-205384 in the elevated plus-maze test in mice". Psicothema. 18 (1): 100–4. PMID 17296016.
  6. ↑ Navarro JF, Burón E, Martín-López M (February 2008). "Effects of SB-205384, a positive modulator of alpha3-subunit-containing GABA-A receptors, on isolation-induced aggression in male mice". Psicothema. 20 (1): 144–7. PMID 18206077.
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