List of dopaminergic drugs

This is a list of dopaminergic drugs. These are pharmaceutical drugs, naturally occurring compounds and other chemicals that influence the function of the neurotransmitter dopamine.

Receptor ligands

Agonists

Adamantanes: Amantadine Memantine Rimantadine

Aminotetralins: 7-OH-DPAT • 8-OH-PBZI Rotigotine UH-232

Benzazepines: 6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959

Ergolines: Bromocriptine Cabergoline Dihydroergocryptine Lisuride Lysergic acid diethylamide (LSD) Pergolide

Dihydrexidine derivatives: 2-OH-NPA A-86,929 Ciladopa Dihydrexidine Dinapsoline Dinoxyline Doxanthrine

Others: A-68,930 A-77,636 A-412,997 ABT-670 ABT-724 Aplindore Apomorphine Aripiprazole Bifeprunox BP-897 CY-208,243 Dizocilpine Etilevodopa Flibanserin Ketamine Melevodopa Modafinil Pardoprunox Phencyclidine PD-128,907 PD-168,077 • PF-219,061 Piribedil Pramipexole • Propylnorapomorphine Pukateine Quinagolide Quinelorane Quinpirole RDS-127 Ro10-5824 Ropinirole Rotigotine Roxindole Salvinorin A SKF-89,145 Sumanirole Terguride Umespirone WAY-100,635

Antagonists

Typical antipsychotics: Acepromazine Azaperone Benperidol Bromperidol Clopenthixol Chlorpromazine Chlorprothixene Droperidol Flupentixol Fluphenazine Fluspirilene Haloperidol Loxapine Mesoridazine Methotrimeprazine Nemonapride Penfluridol Perazine Periciazine Perphenazine Pimozide Prochlorperazine Promazine Sulforidazine Sulpiride Sultopride Thioridazine Thiothixene Trifluoperazine Triflupromazine Trifluperidol Zuclopenthixol

Atypical antipsychotics: Amisulpride Asenapine Blonanserin Cariprazine Carpipramine Clocapramine Clozapine Gevotroline Iloperidone Lurasidone Melperone Molindone Mosapramine Ocaperidone Olanzapine Paliperidone Perospirone Piquindone Quetiapine Remoxipride Risperidone Sertindole Tiospirone Ziprasidone Zotepine

Antiemetics: AS-8112 Alizapride Bromopride Clebopride Domperidone Metoclopramide Thiethylperazine

Others: Amoxapine Buspirone Butaclamol Ecopipam • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) Eticlopride Fananserin L-745,870 Nafadotride Nuciferine PNU-99,194 Raclopride Sarizotan SB-277,011-A SCH-23,390 • SKF-83,566 SKF-83,959 Sonepiprazole Spiperone Spiroxatrine Stepholidine Tetrahydropalmatine Tiapride UH-232 Yohimbine

Reuptake inhibitors

Dopamine transporter (DAT) inhibitors

Piperazines: DBL-583 GBR-12,935 Nefazodone Vanoxerine

Piperidines: 1-(1-(1-Benzothiophen-2-yl)cyclohexyl)piperidine (BTCP) Desoxypipradrol Dextromethylphenidate Difemetorex Ethylphenidate Methylnaphthidate Isopropylphenidate Methylphenidate Phencyclidine Pipradrol

Pyrrolidines: Diphenylprolinol Methylenedioxypyrovalerone (MDPV) • Naphyrone Prolintane Pyrovalerone

Tropanes: 3β-(4'-Chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl)tropane (β-CPPIT) Altropane Brasofensine WIN 35428 (β-CFT) Cocaine Dichloropane Difluoropine N-(2'-Fluoroethyl-)-3β-(4'-chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl)nortropane (FE-β-CPPIT) N-(3'-Fluoropropyl-)-3β-(4'-chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl)nortropane (FP-β-CPPIT) Ioflupane (123I) Iometopane RTI-112 RTI-113 RTI-121 RTI-126 RTI-150 RTI-177 RTI-229 RTI-336 Tenocyclidine Tesofensine Troparil Tropoxane 2β-Propanoyl-3β-(4-tolyl)-tropane (WF-11) 2β-Propanoyl-3β-(2-naphthyl)-tropane (WF-23) 2-Propanoyl-3-(4-isopropylphenyl)-tropane (WF-31) 2α-(Propanoyl)-3β-(2-(6-methoxynaphthyl))-tropane (WF-33)

Others: Adrafinil Armodafinil Amfonelic acid Amineptine Benzatropine (benztropine) Bromantane 2-Butyl-3-(p-tolyl)quinuclidine (BTQ) BTS-74,398 Bupropion (amfebutamone) Ciclazindol Diclofensine Dimethocaine Diphenylpyraline Dizocilpine DOV-102,677 DOV-21,947 DOV-216,303 Etybenzatropine (ethylbenztropine) EXP-561 Fencamine Fencamfamine Fezolamine GYKI-52,895 • Hydrafinil Indatraline Ketamine Lefetamine Levophacetoperane LR-5182 Manifaxine Mazindol Medifoxamine Mesocarb Modafinil Nefopam Nomifensine NS-2359 O-2172 Pridefrine Propylamphetamine Radafaxine SEP-225,289 • SEP-227,162 Sertraline Sibutramine Tametraline Tripelennamine

Vesicular monoamine transporter (VMAT) inhibitors

Deserpidine Ibogaine Reserpine Tetrabenazine

Releasing agents

Morpholines: Fenbutrazate Morazone Phendimetrazine Phenmetrazine

Oxazolines: 4-Methylaminorex (4-MAR, 4-MAX) Aminorex Clominorex Cyclazodone Fenozolone Fluminorex Pemoline Thozalinone

Phenethylamines (also amphetamines, cathinones, phentermines, etc.): 2-Hydroxyphenethylamine (2-OH-PEA) 4-Chlorophenylisobutylamine (4-CAB) • 4-Methylamphetamine (4-MA) • 4-Methylmethamphetamine (4-MMA) Alfetamine Amfecloral Amfepentorex Amfepramone Amphetamine (dextroamphetamine, levoamphetamine) Amphetaminil β-Methylphenethylamine (β-Me-PEA) Benzodioxolylbutanamine (BDB) Benzodioxolylhydroxybutanamine (BOH) Benzphetamine Buphedrone • Butylone Cathine Cathinone Clobenzorex Clortermine D-Deprenyl • Dimethoxyamphetamine (DMA) Dimethoxymethamphetamine (DMMA) Dimethylamphetamine Dimethylcathinone (dimethylpropion, metamfepramone) Ethcathinone (ethylpropion) Ethylamphetamine Ethylbenzodioxolylbutanamine (EBDB) Ethylone Famprofazone Fenethylline Fenproporex • Flephedrone Fludorex Furfenorex • Hordenine Lophophine (homomyristicylamine) Mefenorex Mephedrone Methamphetamine (desoxyephedrine, methedrine; dextromethamphetamine, levomethamphetamine) Methcathinone (methylpropion) Methedrone • Methoxymethylenedioxyamphetamine (MMDA) • Methoxymethylenedioxymethamphetamine (MMDMA) Methylbenzodioxolylbutanamine (MBDB) Methylenedioxyamphetamine (MDA, tenamfetamine) • Methylenedioxyethylamphetamine (MDEA) Methylenedioxyhydroxyamphetamine (MDOH) Methylenedioxymethamphetamine (MDMA) Methylenedioxymethylphenethylamine (MDMPEA, homarylamine) Methylenedioxyphenethylamine (MDPEA, homopiperonylamine) • Methylone • Ortetamine Parabromoamphetamine (PBA) • Parachloroamphetamine (PCA) Parafluoroamphetamine (PFA) Parafluoromethamphetamine (PFMA) Parahydroxyamphetamine (PHA) Paraiodoamphetamine (PIA) Paredrine (norpholedrine, oxamphetamine) Phenethylamine (PEA) Pholedrine Phenpromethamine Prenylamine Propylamphetamine Tiflorex (flutiorex) Tyramine (TRA) Xylopropamine Zylofuramine

Piperazines: 2,5-Dimethoxy-4-bromobenzylpiperazine (2C-B-BZP) Benzylpiperazine (BZP) Methoxyphenylpiperazine (MeOPP, paraperazine) Methylbenzylpiperazine (MBZP) Methylenedioxybenzylpiperazine (MDBZP, piperonylpiperazine)

Others: 2-Amino-1,2-dihydronaphthalene (2-ADN) 2-Aminoindane (2-AI) • 2-Aminotetralin (2-AT) 4-Benzylpiperidine (4-BP) 5-Iodo-2-aminoindane (5-IAI) Clofenciclan Cyclopentamine Cypenamine Cyprodenate • Feprosidnine Gilutensin Heptaminol Hexacyclonate • Indanylaminopropane (IAP) Indanorex Isometheptene • Methylhexanamine Naphthylaminopropane (NAP) Octodrine Phthalimidopropiophenone Propylhexedrine (levopropylhexedrine) Tuaminoheptane (tuamine)

Enzyme inhibitors

Synthesis inhibitors

Phenylalanine hydroxylase inhibitors

3,4-Dihydroxystyrene

Tyrosine hydroxylase inhibitors

3-Iodotyrosine • Aquayamycin • Bulbocapnine Metirosine • Oudenone

Aromatic L-amino acid decarboxylase inhibitors (DOPA decarboxylase inhibitors)

Benserazide Carbidopa Genistein Methyldopa

Degradation inhibitors

Monoamine oxidase (MAO) inhibitors

Nonselective: Benmoxin Caroxazone Echinopsidine Furazolidone Hydralazine Indantadol Iproclozide Iproniazid Isocarboxazid Isoniazid Linezolid Mebanazine Metfendrazine Nialamide Octamoxin Paraxazone Phenelzine Pheniprazine Phenoxypropazine Pivalylbenzhydrazine Procarbazine Safrazine Tranylcypromine

MAO-A selective: Amiflamine Bazinaprine • Befloxatone Befol Brofaromine Cimoxatone Clorgiline Esuprone • Harmala alkaloids (harmine, harmaline, tetrahydroharmine, harman, norharman, etc.) Methylene blue Metralindole Minaprine Moclobemide Pirlindole Sercloremine Tetrindole Toloxatone Tyrima

MAO-B selective: D-Deprenyl Selegiline (L-deprenyl) Ladostigil Lazabemide • Milacemide Mofegiline Pargyline Rasagiline Safinamide

Catechol-O-methyl transferase (COMT) inhibitors

Entacapone Nitecapone Opicapone Tolcapone

Dopamine beta hydroxylase inhibitors

Bupicomide Disulfiram • Dopastin • Fusaric acid • Nepicastat • Phenopicolinic acid • Tropolone

Others

Precursors

L-Phenylalanine

L-Phenylalanine → L-tyrosine → L-DOPA (levodopa)

Cofactors

Ferrous iron (Fe2+) Tetrahydrobiopterin Vitamin B3 (niacin, nicotinamide → NADPH) Vitamin B6 (pyridoxine, pyridoxamine, pyridoxal → pyridoxal phosphate) Vitamin B9 (folic acid → tetrahydrofolic acid) Vitamin C (ascorbic acid) Zinc (Zn2+)

Activity enhancers

Benzofuranylpropylaminopentane (BPAP) Phenylpropylaminopentane (PPAP) Selegiline (L-deprenyl)

Toxins

Oxidopamine (6-hydroxydopamine)

Levodopa prodrugs

XP21279

References

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