Ibuprofen

Ibuprofen
(R)-ibuprofen
Names
Pronunciation/ˈaɪbjuːproʊfɛn/, /aɪbjuːˈproʊfən/, EYE-bew-PROH-fən
Trade namesAdvil, Motrin, Nurofen, others
Other namesisobutylphenylpropionic acid
IUPAC name
  • (RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid
Clinical data
Drug classNonsteroidal anti-inflammatory drug (NSAID)
Main usesPain, fever, inflammation[1]
Side effectsHeartburn, rash[1]
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • AU: C[2]
  • US: C (Risk not ruled out)[2]
  • D (US) at ≥30 weeks of gestation, due to the potential for premature closure of the ductus arteriosus[2]
BreastfeedingSafe[3]
Routes of
use		By mouth, rectal, topical, intravenous
Onset of action30 min[4]
Defined daily dose1.2 g (by mouth) or
1.2 g (parenteral) or
1.2 g (rectal) for pain relief[5] and
30 mg (parenteral) for treatment of ischemic heart diseases[6]
External links
AHFS/Drugs.comMonograph
MedlinePlusa682159
Legal
License data
Legal status
Pharmacokinetics
Bioavailability80–100% (by mouth),[7] 87% (rectal)
Protein binding98%[8]
MetabolismLiver (CYP2C9)[8]
Metabolitesibuprofen glucuronide, 2-hydroxyibuprofen, 3-hydroxyibuprofen, carboxy-ibuprofen, 1-hydroxyibuprofen
Elimination half-life2–4 h[9]
ExcretionUrine (95%)[8][10]
Chemical and physical data
FormulaC13H18O2
Molar mass206.285 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
Density1.03 g/ml g/cm3
Melting point75 to 78 °C (167 to 172 °F)
Boiling point157 °C (315 °F) at 4 mmHg
Solubility in water0.021 mg/mL (20 °C)
SMILES
  • CC(C)Cc1ccc(cc1)[C@@H](C)C(=O)O
InChI
  • InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15) checkY
  • Key:HEFNNWSXXWATRW-UHFFFAOYSA-N checkY

Ibuprofen is a medication in the nonsteroidal anti-inflammatory drug (NSAID) class that is used for treating pain, fever, and inflammation.[1] This includes painful menstrual periods, migraines, and rheumatoid arthritis.[1] It may also be used to close a patent ductus arteriosus in a premature baby.[1] It can be used by mouth or intravenously.[1] It typically begins working within an hour.[1]

Common side effects include heartburn and a rash.[1] Compared to other NSAIDs, it may have fewer side effects such as gastrointestinal bleeding.[11] It increases the risk of heart failure, kidney failure, and liver failure.[1] At low doses, it does not appear to increase the risk of heart attack; however, at higher doses it may.[11] Ibuprofen can also worsen asthma.[11] While it is unclear if it is safe in early pregnancy,[1] it appears to be harmful in later pregnancy and therefore is not recommended.[12] Use when breastfeeding is safe.[3] Like other NSAIDs, it works by inhibiting the production of prostaglandins by decreasing the activity of the enzyme cyclooxygenase.[1] Ibuprofen is a weaker anti-inflammatory agent than other NSAIDs.[11]

Ibuprofen was discovered in 1961 by Stewart Adams at Boots UK Limited and initially marketed as Brufen.[13] It is available under a number of trade names, including Nurofen, Advil and Motrin.[1][14] It was first marketed in 1969 in the United Kingdom and in the United States in 1974.[1][13] It is on the World Health Organization's List of Essential Medicines.[15] It is available as a generic medication.[1] The wholesale cost in the developing world is between US$0.01 and US$0.04 per dose.[16] In the United States, it costs about US$0.05 per dose.[1] In 2017, it was the 28th most commonly prescribed medication in the United States, with more than 24 million prescriptions.[17][18]

Medical uses

Example of some 200 mg ibuprofen tablets

Ibuprofen is used primarily to treat fever (including post-vaccination fever), mild to moderate pain (including pain relief after surgery), painful menstruation, osteoarthritis, dental pain, headaches, and pain from kidney stones. About 60% of people respond to any NSAID; those who do not respond well to a particular one may respond to another.[19]

It is used for inflammatory diseases such as juvenile idiopathic arthritis and rheumatoid arthritis.[20][21] It is also used for pericarditis and patent ductus arteriosus.[22][23]

In children under the age of two it works better than acetaminophen for fever or pain with similar safety.[24]

Ibuprofen lysine

In some countries, ibuprofen lysine (the lysine salt of ibuprofen, sometimes called "ibuprofen lysinate") is used for the same conditions as ibuprofen; the lysine salt is used because it is more water-soluble.[25] In 2006, ibuprofen lysine was approved in the USA for closure of patent ductus arteriosus in premature infants weighing between 500 and 1,500 grams (1 and 3 lb), who are no more than 32 weeks' gestational age when usual medical management (such as fluid restriction, diuretics, and respiratory support) is not effective.[26]

Dosage

The defined daily dose is 1.2 g (by mouth) or 1.2 g (parenteral) or 1.2 g (rectal) for pain relief[27] and 30 mg (parenteral) for treatment of ischemic heart diseases[6] In those over the age of 12 the dose is generally 200 to 400 mg three to four times a day while in those over the age of three months the dose is 5 to 10 mg/kg three to four times per day.[28] In rheumatologic diseases doses up to 40 mg/kg per day in children or 3,200 mg per day in adults may be used.[28]

Side effects

See also: Nonsteroidal anti-inflammatory drug

Side effects include nausea, dyspepsia, diarrhea, constipation, gastrointestinal ulceration/bleeding, headache, dizziness, rash, salt and fluid retention, and high blood pressure.[21][29]

Infrequent adverse effects include esophageal ulceration, heart failure, high blood levels of potassium, kidney impairment, confusion, and bronchospasm.[21] Ibuprofen can exacerbate asthma, sometimes fatally.[30]

Ibuprofen may be quantified in blood, plasma, or serum to demonstrate the presence of the drug in a person having experienced an anaphylactic reaction, confirm a diagnosis of poisoning in people who are hospitalized, or assist in a medicolegal death investigation. A monograph relating ibuprofen plasma concentration, time since ingestion, and risk of developing renal toxicity in people who have overdosed has been published.[31]

Cardiovascular risk

Along with several other NSAIDs, chronic ibuprofen use has been found correlated with risk of progression to hypertension in women, though less than for acetaminophen,[32] and myocardial infarction (heart attack),[33] particularly among those chronically using higher doses. On 9 July 2015, the U.S. Food and Drug Administration (FDA) toughened warnings of increased heart attack and stroke risk associated with ibuprofen and related NSAIDs; the NSAID aspirin is not included in this warning.[34] The European Medicines Agency (EMA) issued similar warnings in 2015.[35][36]

Skin

Along with other NSAIDs, ibuprofen has been associated with the onset of bullous pemphigoid or pemphigoid-like blistering.[37] As with other NSAIDs, ibuprofen has been reported to be a photosensitising agent,[38] but it is considered a weak photosensitising agent compared to other members of the 2-arylpropionic acid class. Like other NSAIDs, ibuprofen is an extremely rare cause of the autoimmune disease Stevens–Johnson syndrome (SJS).[39][40] Ibuprofen is also an extremely rare cause of toxic epidermal necrolysis.[41]

Interactions

Alcohol

Drinking alcohol when taking ibuprofen may increase the risk of stomach bleeding.[42]

Aspirin

According to the Food and Drug Administration (FDA), "ibuprofen can interfere with the antiplatelet effect of low-dose aspirin, potentially rendering aspirin less effective when used for cardioprotection and stroke prevention." Allowing sufficient time between doses of ibuprofen and immediate-release (IR) aspirin can avoid this problem. The recommended elapsed time between a dose of ibuprofen and a dose of aspirin depends on which is taken first. It would be 30 minutes or more for ibuprofen taken after IR aspirin, and eight hours or more for ibuprofen taken before IR aspirin. However, this timing cannot be recommended for enteric-coated aspirin. But, if ibuprofen is taken only occasionally without the recommended timing, the reduction of the cardioprotection and stroke prevention of a daily aspirin regimen is minimal.[43]

Paracetamol

Ibuprofen combined with paracetamol is considered generally safe in children for short-term usage.[44]

Overdose

Ibuprofen overdose has become common since it was licensed for OTC use. Many overdose experiences are reported in the medical literature, although the frequency of life-threatening complications from ibuprofen overdose is low.[45] Human response in cases of overdose ranges from absence of symptoms to fatal outcome despite intensive-care treatment. Most symptoms are an excess of the pharmacological action of ibuprofen, and include abdominal pain, nausea, vomiting, drowsiness, dizziness, headache, ear ringing, and nystagmus. Rarely, more severe symptoms, such as gastrointestinal bleeding, seizures, metabolic acidosis, high blood levels of potassium, low blood pressure, slow heart rate, fast heart rate, atrial fibrillation, coma, liver dysfunction, acute kidney failure, cyanosis, respiratory depression, and cardiac arrest have been reported.[46] The severity of symptoms varies with the ingested dose and the time elapsed; however, individual sensitivity also plays an important role. Generally, the symptoms observed with an overdose of ibuprofen are similar to the symptoms caused by overdoses of other NSAIDs.

Correlation between severity of symptoms and measured ibuprofen plasma levels is weak. Toxic effects are unlikely at doses below 100 mg/kg, but can be severe above 400 mg/kg (around 150 tablets of 200 mg units for an average man);[47] however, large doses do not indicate the clinical course is likely to be lethal.[48] A precise lethal dose is difficult to determine, as it may vary with age, weight, and concomitant conditions of the individual person.

Treatment to address an ibuprofen overdose is based on how the symptoms present. In cases presenting early, decontamination of the stomach is recommended. This is achieved using activated charcoal; charcoal adsorbs the drug before it can enter the bloodstream. Gastric lavage is now rarely used, but can be considered if the amount ingested is potentially life-threatening, and it can be performed within 60 minutes of ingestion. Purposeful vomiting is not recommended.[49] The majority of ibuprofen ingestions produce only mild effects and the management of overdose is straightforward. Standard measures to maintain normal urine output should be instituted and kidney function monitored.[47] Since ibuprofen has acidic properties and is also excreted in the urine, forced alkaline diuresis is theoretically beneficial. However, because ibuprofen is highly protein-bound in the blood, the kidneys' excretion of unchanged drug is minimal. Forced alkaline diuresis is, therefore, of limited benefit.[50]

Miscarriage

A study of pregnant women suggests that those taking any type or amount of NSAIDs (including ibuprofen, diclofenac and naproxen) were 2.4 times more likely to miscarry than those not taking the medications.[51] However, an Israeli study found no increased risk of miscarriage in the group of mothers using NSAIDs.[52]

Pharmacology

NSAIDs such as ibuprofen work by inhibiting the cyclooxygenase (COX) enzymes, which convert arachidonic acid to prostaglandin H2 (PGH2). PGH2, in turn, is converted by other enzymes to several other prostaglandins (which are mediators of pain, inflammation, and fever) and to thromboxane A2 (which stimulates platelet aggregation, leading to the formation of blood clots).

Like aspirin and indomethacin, ibuprofen is a nonselective COX inhibitor, in that it inhibits two isoforms of cyclooxygenase, COX-1 and COX-2. The analgesic, antipyretic, and anti-inflammatory activity of NSAIDs appears to operate mainly through inhibition of COX-2, which decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever, and swelling. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Inhibition of COX-1 instead would be responsible for unwanted effects on the gastrointestinal tract.[53] However, the role of the individual COX isoforms in the analgesic, anti-inflammatory, and gastric damage effects of NSAIDs is uncertain and different compounds cause different degrees of analgesia and gastric damage.[54]

Ibuprofen is administered as a racemic mixture. The R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo. The S-enantiomer is believed to be the more pharmacologically active enantiomer.[55] The R-enantiomer is converted through a series of three main enzymes. These enzymes include acyl-CoA-synthetase, which converts the R-enantiomer to (-)-R-ibuprofen I-CoA; 2-arylpropionyl-CoA epimerase, which converts (-)-R-ibuprofen I-CoA to (+)-S-Ibuprofen I-CoA; and hydrolase, which converts (+)-S-ibuprofen I-CoA to the S-enantiomer.[41] In addition to the conversion of ibuprofen to the S-enantiomer, the body can metabolize ibuprofen to several other compounds, including numerous hydroxyl, carboxyl and glucuronyl metabolites. Virtually all of these have no pharmacological effects.[41]

Pharmacokinetics

After oral administration, peak serum concentration is reached after 1–2 hours and up to 99% of the drug is bound to plasma proteins.[56] The majority of ibuprofen is metabolised and eliminated within 24 hours in the urine; however, 1% of the unchanged drug is removed through biliary excretion.[55]

Chemistry

(R)-ibuprofen
(S)-ibuprofen

Ibuprofen is practically insoluble in water, but very soluble in most organic solvents like ethanol (66.18 g/100mL at 40 °C for 90% EtOH), methanol, acetone and dichloromethane.[57]

The original synthesis of ibuprofen by the Boots Group started with the compound 2-methylpropylbenzene. The synthesis took six steps. A modern, greener technique for the synthesis involves only three steps.[58]

Stereochemistry

It is an optically active compound with both S and R-isomers, of which the S (dextrorotatory) isomer is the more biologically active; this isomer has also been isolated and used medically (see dexibuprofen for details).[57]

Ibuprofen is produced industrially as a racemate. The compound, like other 2-arylpropionate derivatives (including ketoprofen, flurbiprofen, naproxen, etc.), does contain a stereocenter in the α-position of the propionate moiety. So two enantiomers of ibuprofen occur, with the potential for different biological effects and metabolism for each enantiomer.

An isomerase (alpha-methylacyl-CoA racemase) converts (R)-ibuprofen to the active (S)-enantiomer.[59][60][61]

History

The Royal Society of Chemistry blue plaque at BioCity Nottingham

Ibuprofen was derived from propionic acid by the research arm of Boots Group during the 1960s.[62] The name is derived from the 3 functional groups: isobutyl (ibu) propionic acid (pro) phenyl (fen). Its discovery was the result of research during the 1950s and 1960s to find a safer alternative to aspirin.[13][63] The molecule was discovered and synthesized by a team led by Stewart Adams, with a patent application filed in 1961.[13] Adams initially tested the drug as treatment for his hangover.[64]

The drug was launched as a treatment for rheumatoid arthritis in the United Kingdom in 1969, and in the United States in 1974. Later, in 1983 and 1984, it became the first NSAID (other than aspirin) to be available over the counter (OTC) in these two countries.[13][63] Dr. Adams was subsequently awarded an Order of the British Empire (OBE) in 1987. Boots was awarded the Queen's Award for Technical Achievement in 1987 for the development of the drug.[13]

In November 2013, work on ibuprofen was recognized by the erection of a Royal Society of Chemistry blue plaque at Boots' Beeston Factory site in Nottingham, which reads:[65]

In recognition of the work during the 1980s by The Boots Company PLC on the development of ibuprofen which resulted in its move from prescription only status to over the counter sale, therefore expanding its use to millions of people worldwide

and another at BioCity Nottingham, the site of the original laboratory, which reads:[65]

In recognition of the pioneering research work, here on Pennyfoot Street, by Dr Stewart Adams and Dr John Nicholson in the Research Department of Boots which led to the discovery of ibuprofen used by millions worldwide for the relief of pain.

Society and culture

Cost

The wholesale cost in the developing world is between US$0.01 and US$0.04 per dose.[16] In the United States, it costs about US$0.05 per dose.[1] In 2017, it was the 28th most commonly prescribed medication in the United States, with more than 24 million prescriptions.[17][18]

  • Ibuprofen costs (US)
    Ibuprofen costs (US)
  • Ibuprofen prescriptions (US)
    Ibuprofen prescriptions (US)

Availability

See also: Ibuprofen brand names
A bottle of generic ibuprofen

Ibuprofen was made available under prescription in the United Kingdom in 1969, and in the United States in 1974.[66] In the years since, the good tolerability profile, along with extensive experience in the population, as well as in so-called phase-IV trials (postapproval studies), have resulted in the availability of ibuprofen OTC in pharmacies worldwide, as well as in supermarkets and other general retailers.

Ibuprofen is its International nonproprietary name (INN), British Approved Name (BAN), Australian Approved Name (AAN) and United States Adopted Name (USAN). In the U.S., Motrin has been on the market since 1974,[67] and Advil has been on the market since 1984.[68] Ibuprofen is commonly available in the United States up to the FDA's 1984 dose limit OTC, rarely used higher by prescription.[69]

In 2009, the first injectable formulation of ibuprofen was approved in the United States, under the trade name Caldolor.[70][71]

Route

It can be used by mouth, as a tablet, capsule or suspension, or intravenously.[1]

Research

Ibuprofen is sometimes used for the treatment of acne because of its anti-inflammatory properties, and has been sold in Japan in topical form for adult acne.[72][73] As with other NSAIDs, ibuprofen may be useful in the treatment of severe orthostatic hypotension (low blood pressure when standing up).[74] NSAIDs are of unclear utility in the prevention and treatment of Alzheimer's disease.[75][76]

Ibuprofen has been associated with a lower risk of Parkinson's disease, and may delay or prevent it. Aspirin, other NSAIDs, and paracetamol (acetaminophen) had no effect on the risk for Parkinson's.[77] In March 2011, researchers at Harvard Medical School announced in Neurology that ibuprofen had a neuroprotective effect against the risk of developing Parkinson's disease.[78][79][80] People regularly consuming ibuprofen were reported to have a 38% lower risk of developing Parkinson's disease, but no such effect was found for other pain relievers, such as aspirin and paracetamol. Use of ibuprofen to lower the risk of Parkinson's disease in the general population would not be problem-free, given the possibility of adverse effects on the urinary and digestive systems.[81]

Some dietary supplements might be dangerous to take along with ibuprofen and other NSAIDs, but as of 2016 more research needs to be conducted to be certain. These supplements include those that can prevent platelet aggregation, including ginkgo, garlic, ginger, bilberry, dong quai, feverfew, ginseng, turmeric, meadowsweet, and willow; those that contain coumarin, including chamomile, horse chestnut, fenugreek and red clover; and those that increase the risk of bleeding, like tamarind.[82]

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  2. 1 2 3 Use During Pregnancy and Breastfeeding
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External sites:
Identifiers:
  • GB patent 971700, Stewart Sanders Adams & John Stuart Nicholson, "Anti-Inflammatory Agents", published 1964-09-30, assigned to BOOTS PURE DRUG CO LTD 
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