Methaphenilene

Methaphenilene is an antihistamine and anticholinergic.

Methaphenilene
Identifiers
IUPAC name
  • N,N-Dimethyl-N′-phenyl-N′-(thiophen-2-ylmethyl)ethane-1,2-diamine
CAS Number
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.007.074
Chemical and physical data
FormulaC15H20N2S
Molar mass260.40 g·mol−1
3D model (JSmol)
SMILES
  • CN(C)CCN(Cc1cccs1)c2ccccc2
InChI
  • InChI=InChI=1S/C15H20N2S/c1-16(2)10-11-17(13-15-9-6-12-18-15)14-7-4-3-5-8-14/h3-9,12H,10-11,13H2,1-2H3 Y
  • Key:LDYJXVUOVPVZKA-UHFFFAOYSA-N Y
Not to be confused with Methapyrilene.

Synthesis

Methaphenilene can be synthesized from N,N-dimethyl-N′-phenylethane-1,2-diamine by alkylation with 2-(chloromethyl)thiophene.[1]

Methaphenilene synthesis

See also

References
  1. Leonard F, Solmssen UV (June 1948). "Thenyl Substituted Diamines with Antihistaminic Activity". Journal of the American Chemical Society. 70 (6): 2064–7. doi:10.1021/ja01186a023. PMID 18863797.
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