SERPINI1
SERPINI1 (Serpin family I member 1) هوَ بروتين يُشَفر بواسطة جين SERPINI1 في الإنسان.[1][1]
الوظيفة
المراجع
- "Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1"، مؤرشف من الأصل في 07 مارس 2010.
قراءة متعمقة
- Yepes M؛ Lawrence DA (2004)، "Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system."، Thromb. Haemost.، 91 (3): 457–64، doi:10.1160/TH03-12-0766، PMID 14983220.
- "Human neuroserpin (PI12): cDNA cloning and chromosomal localization to 3q26."، Genomics، 40 (1): 55–62، 1997، doi:10.1006/geno.1996.4514، PMID 9070919.
- "Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival."، J. Biol. Chem.، 272 (52): 33062–7، 1998، doi:10.1074/jbc.272.52.33062، PMID 9407089.
- "Familial dementia caused by polymerization of mutant neuroserpin."، Nature، 401 (6751): 376–9، 1999، doi:10.1038/43894، PMID 10517635.
- "Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26."، Genes Chromosomes Cancer، 29 (3): 240–55، 2000، doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1029>3.0.CO;2-A، PMID 10992299.
- Belorgey D؛ Crowther DC؛ Mahadeva R؛ Lomas DA (2002)، "Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro."، J. Biol. Chem.، 277 (19): 17367–73، doi:10.1074/jbc.M200680200، PMID 11880376.
- "Association between conformational mutations in neuroserpin and onset and severity of dementia."، Lancet، 359 (9325): 2242–7، 2002، doi:10.1016/S0140-6736(02)09293-0، PMID 12103288.
- Barker-Carlson K؛ Lawrence DA؛ Schwartz BS (2003)، "Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro."، J. Biol. Chem.، 277 (49): 46852–7، doi:10.1074/jbc.M207740200، PMID 12228252.
- "Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells."، J. Neurochem.، 82 (6): 1406–15، 2002، doi:10.1046/j.1471-4159.2002.01100.x، PMID 12354288.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."، Proc. Natl. Acad. Sci. U.S.A.، 99 (26): 16899–903، 2003، Bibcode:2002PNAS...9916899M، doi:10.1073/pnas.242603899، PMC 139241، PMID 12477932.
- Miranda E؛ Römisch K؛ Lomas DA (2004)، "Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum."، J. Biol. Chem.، 279 (27): 28283–91، doi:10.1074/jbc.M313166200، PMID 15090543.
- "Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system."، Thromb. Haemost.، 92 (2): 358–68، 2005، doi:10.1267/THRO04080358، PMID 15269833.
- "Neuroserpin Portland (Ser52Arg) is trapped as an inactive intermediate that rapidly forms polymers: implications for the epilepsy seen in the dementia FENIB."، Eur. J. Biochem.، 271 (16): 3360–7، 2004، doi:10.1111/j.1432-1033.2004.04270.x، PMID 15291813.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."، Genome Res.، 14 (10B): 2121–7، 2004، doi:10.1101/gr.2596504، PMC 528928، PMID 15489334.
- Onda M؛ Belorgey D؛ Sharp LK؛ Lomas DA (2005)، "Latent S49P neuroserpin forms polymers in the dementia familial encephalopathy with neuroserpin inclusion bodies."، J. Biol. Chem.، 280 (14): 13735–41، doi:10.1074/jbc.M413282200، PMID 15664988.
- "Towards a proteome-scale map of the human protein-protein interaction network."، Nature، 437 (7062): 1173–8، 2005، Bibcode:2005Natur.437.1173R، doi:10.1038/nature04209، PMID 16189514.
- "Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease."، J. Biol. Chem.، 281 (39): 29268–77، 2006، doi:10.1074/jbc.M600690200، PMID 16849336.
- "Two non-homologous brain diseases-related genes, SERPINI1 and PDCD10, are tightly linked by an asymmetric bidirectional promoter in an evolutionarily conserved manner."، BMC Mol. Biol.، 8: 2، 2007، doi:10.1186/1471-2199-8-2، PMC 1796892، PMID 17212813.
- "Clinical and neuropathologic study of a French family with a mutation in the neuroserpin gene."، Neurology، 69 (1): 79–83، 2007، doi:10.1212/01.wnl.0000265052.99144.b5، PMID 17606885.
بوابة طب
بوابة الكيمياء الحيوية
بوابة علم الأحياء الخلوي والجزيئي
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