HEXIM1
HEXIM1 (Hexamethylene bisacetamide inducible 1) هوَ بروتين يُشَفر بواسطة جين HEXIM1 في الإنسان.[1][2][3]
المراجع
- "Structure, expression, and functional characterization of the mouse CLP-1 gene"، Gene، 292 (1–2): 245–59، يوليو 2002، doi:10.1016/S0378-1119(02)00596-6، PMID 12119119.
- "Entrez Gene: HEXIM1 hexamethylene bis-acetamide inducible 1"، مؤرشف من الأصل في 05 ديسمبر 2010.
- "MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner"، Mol Cell Biol، 23 (14): 4859–69، يونيو 2003، doi:10.1128/MCB.23.14.4859-4869.2003، PMC 162212، PMID 12832472.
قراءة متعمقة
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags"، Proc. Natl. Acad. Sci. U.S.A.، 97 (7): 3491–6، 2000، doi:10.1073/pnas.97.7.3491، PMC 16267، PMID 10737800.
- "Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells"، Genes Cells، 8 (2): 95–107، 2003، doi:10.1046/j.1365-2443.2003.00618.x، PMID 12581153.
- "Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors"، Cancer Res.، 63 (16): 5151–8، 2003، PMID 12941847.
- "Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA"، Mol. Cell، 12 (4): 971–82، 2003، doi:10.1016/S1097-2765(03)00388-5، PMID 14580347.
- "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation"، Cell، 117 (3): 311–21، 2004، doi:10.1016/S0092-8674(04)00342-3، PMID 15109492.
- "A Human Immunodeficiency Virus Type 1 Tat-Like Arginine-Rich RNA-Binding Domain Is Essential for HEXIM1 To Inhibit RNA Polymerase II Transcription through 7SK snRNA-Mediated Inactivation of P-TEFb"، Mol. Cell. Biol.، 24 (12): 5094–105، 2004، doi:10.1128/MCB.24.12.5094-5105.2004، PMC 419863، PMID 15169877.
- "Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor"، EMBO J.، 23 (13): 2608–19، 2005، doi:10.1038/sj.emboj.7600275، PMC 449783، PMID 15201869.
- "Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription"، J. Biol. Chem.، 280 (16): 16368–76، 2005، doi:10.1074/jbc.M500912200، PMID 15713661.
- "HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK"، J. Biol. Chem.، 280 (16): 16360–7، 2005، doi:10.1074/jbc.M500424200، PMID 15713662.
- "Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat"، J. Biol. Chem.، 280 (26): 24968–77، 2005، doi:10.1074/jbc.M501431200، PMID 15855166.
- "The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1"، Oncogene، 24 (36): 5576–88، 2005، doi:10.1038/sj.onc.1208728، PMID 15940264.
- "HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b"، Proc. Natl. Acad. Sci. U.S.A.، 102 (24): 8555–60، 2005، doi:10.1073/pnas.0409863102، PMC 1150813، PMID 15941832.
- "Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186"، J. Biol. Chem.، 280 (31): 28819–26، 2005، doi:10.1074/jbc.M502712200، PMID 15965233.
- "Inhibition of Tat activity by the HEXIM1 protein"، Retrovirology، 2: 42، 2006، doi:10.1186/1742-4690-2-42، PMC 1183248، PMID 15992410.
- "Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer"، J. Biol. Chem.، 280 (34): 30619–29، 2005، doi:10.1074/jbc.M502471200، PMID 15994294.
- "Towards a proteome-scale map of the human protein-protein interaction network"، Nature، 437 (7062): 1173–8، 2005، doi:10.1038/nature04209، PMID 16189514.
بوابة الكيمياء الحيوية
بوابة طب
بوابة علم الأحياء الخلوي والجزيئي
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