HIC1
HIC1 (HIC ZBTB transcriptional repressor 1) هوَ بروتين يُشَفر بواسطة جين HIC1 في الإنسان.[1]
الوظيفة
المراجع
- "Entrez Gene: HIC1 hypermethylated in cancer 1"، مؤرشف من الأصل في 05 ديسمبر 2010.
قراءة متعمقة
- "[Chromosome arm 17p13.3: could HIC1 be the one ?]"، Med Sci (Paris)، 22 (1): 54–61، 2006، doi:10.1051/medsci/200622154، PMID 16386221.
- "p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3."، Nat. Med.، 1 (6): 570–7، 1995، doi:10.1038/nm0695-570، PMID 7585125.
- "Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer."، Oncogene، 16 (16): 2159–64، 1998، doi:10.1038/sj.onc.1201976، PMID 9572497.
- "The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved."، Biochim. Biophys. Acta، 1443 (1–2): 230–2، 1999، doi:10.1016/s0167-4781(98)00219-x، PMID 9838134.
- "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B."، Proc. Natl. Acad. Sci. U.S.A.، 96 (26): 14831–6، 2000، doi:10.1073/pnas.96.26.14831، PMC 24733، PMID 10611298.
- "Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53."، J. Biol. Chem.، 276 (5): 3078–89، 2001، doi:10.1074/jbc.M008690200، PMID 11073960.
- "Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1."، Biochem. Biophys. Res. Commun.، 287 (2): 427–34، 2001، doi:10.1006/bbrc.2001.5624، PMID 11554746.
- "The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif."، Mol. Cell. Biol.، 22 (13): 4890–901، 2002، doi:10.1128/MCB.22.13.4890-4901.2002، PMC 133903، PMID 12052894.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."، Proc. Natl. Acad. Sci. U.S.A.، 99 (26): 16899–903، 2003، doi:10.1073/pnas.242603899، PMC 139241، PMID 12477932.
- "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3."، Am. J. Hum. Genet.، 72 (4): 918–30، 2003، doi:10.1086/374320، PMC 1180354، PMID 12621583.
- "Aberrant methylation of the HIC1 promoter is a frequent event in specific pediatric neoplasms."، Clin. Cancer Res.، 9 (10 Pt 1): 3674–8، 2004، PMID 14506157.
- "Epigenetic silencing of the HIC-1 gene in human medulloblastomas."، J. Neuropathol. Exp. Neurol.، 62 (11): 1192–201، 2004، PMID 14656076.
- "Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling."، Carcinogenesis، 25 (5): 661–8، 2004، doi:10.1093/carcin/bgh055، PMID 14688019.
- "Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1."، Oncogene، 23 (22): 4023–31، 2004، doi:10.1038/sj.onc.1207504، PMID 15007385.
- "The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties."، J. Biol. Chem.، 279 (37): 38313–24، 2004، doi:10.1074/jbc.M401610200، PMID 15231840.
- "Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis."، Cancer Cell، 6 (4): 387–98، 2004، doi:10.1016/j.ccr.2004.08.030، PMID 15488761.
- "Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1."، Oncogene، 25 (14): 2030–9، 2006، doi:10.1038/sj.onc.1209240، PMID 16301995.
- "HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies."، EMBO J.، 25 (11): 2326–37، 2006، doi:10.1038/sj.emboj.7601147، PMC 1478201، PMID 16724116.
- "A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP."، FEBS J.، 273 (13): 2879–90، 2006، doi:10.1111/j.1742-4658.2006.05301.x، PMID 16762039.
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