CYP2A7
CYP2A7 (Cytochrome P450 family 2 subfamily A member 7) هوَ بروتين يُشَفر بواسطة جين CYP2A7 في الإنسان.[1][2][3]
الوظيفة
المراجع
- "Entrez Gene: CYP2A7"، مؤرشف من الأصل في 05 ديسمبر 2010.
- "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants"، Pharmacogenetics، 14 (1): 1–18، يناير 2004، doi:10.1097/00008571-200401000-00001، PMID 15128046، مؤرشف من الأصل في 11 مارس 2012.
- "A Genetic Polymorphism in Coumarin 7-Hydroxylation: Sequence of the Human CYP2A Gnes and Identification of Variant CYP2A6 Alleles"، Am. J. Hum. Genet.، 57 (3): 651–60، سبتمبر 1995، PMC 1801261، PMID 7668294.
قراءة متعمقة
- "Structure of the human lung cytochrome P450 2A13"، J. Biol. Chem.، 282 (23): 17306–13، 2007، doi:10.1074/jbc.M702361200، PMID 17428784.
- "Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population"، Pharmacogenomics، 10 (3): 359–74، 2009، doi:10.2217/14622416.10.3.359، PMID 19290787.
- "The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis"، Pharmacogenetics، 5 (Special Issue): S123–8، 1995، doi:10.1097/00008571-199512001-00013، PMID 7581481.
- "Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility"، Biochem. Biophys. Res. Commun.، 317 (2): 662–9، 2004، doi:10.1016/j.bbrc.2004.03.092، PMID 15063809.
- "CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences"، Carcinogenesis، 30 (7): 1161–9، 2009، doi:10.1093/carcin/bgp102، PMID 19414505.
- "Molecular genetics of the human cytochrome P450 monooxygenase superfamily"، Xenobiotica، 28 (12): 1129–65، 1998، doi:10.1080/004982598238868، PMID 9890157.
- "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects"، J. Hum. Genet.، 54 (6): 317–23، 2009، doi:10.1038/jhg.2009.31، PMID 19343046.
- "Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen"، Drug Metab. Dispos.، 32 (12): 1516–21، 2004، doi:10.1124/dmd.104.001370، PMID 15333516.
- "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants"، Pharmacogenetics، 14 (1): 1–18، 2004، doi:10.1097/00008571-200401000-00001، PMID 15128046.
- "Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation"، Arch. Biochem. Biophys.، 427 (2): 143–53، 2004، doi:10.1016/j.abb.2004.03.016، PMID 15196988.
- "Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma"، Arch. Gynecol. Obstet.، 274 (6): 367–71، 2006، doi:10.1007/s00404-006-0201-8، PMID 16835796.
- "Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China"، Cancer Detect. Prev.، 32 (5–6): 416–23، 2009، doi:10.1016/j.cdp.2009.02.003، PMID 19303722.
- "Eighteen novel polymorphisms of the CYP2A13 gene in Japanese"، Drug Metab. Pharmacokinet.، 18 (1): 86–90، 2003، doi:10.2133/dmpk.18.86، PMID 15618722.
- "Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK"، Cancer Res.، 63 (22): 8057–61، 2003، PMID 14633739.
- "Arg257Cys polymorphism of CYP2A13 in a Chinese population"، Clin. Chim. Acta، 343 (1–2): 213–6، 2004، doi:10.1016/j.cccn.2004.01.017، PMID 15115698.
- "Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers"، Drug Metab. Dispos.، 36 (11): 2316–23، 2008، doi:10.1124/dmd.108.022822، PMC 2597635، PMID 18669584.
- "CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations"، Xenobiotica، 35 (7): 661–9، 2005، doi:10.1080/00498250500202171، PMID 16316926.
- "CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk"، Pancreas، 39 (2): 144–8، 2010، doi:10.1097/MPA.0b013e3181bab6c2، PMID 19812523.
- "Genetic polymorphisms of CYP2A13 and its relationship to nasopharyngeal carcinoma in the Cantonese population"، J Transl Med، 2 (1): 24، 2004، doi:10.1186/1479-5876-2-24، PMC 455696، PMID 15222883.
- "A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers"، Postgrad Med J، 85 (1008): 515–24، 2009، doi:10.1136/pgmj.2008.077107، PMID 19789190.
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